Publications of Nina Wettschureck

Kwon, J.; Haruya, K.; Mattonet, K.; Guenther, S.; Hahnefeld, L.; Shamsara, J.; Heering, J.; Kurz, M.; Kirchhofer, S.; Krasel, C. et al.; Ulrich, M.; Persechino, M.; Murthy, S.; Orlandi, C.; Sadik, C. D.; Geisslinger, G.; Buenemann, M.; Kolb, P.; Offermanns, S.; Wettschureck, N.: Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling. NATURE COMMUNICATIONS 16 (1), 1448 (2025)

Jin, Y.-J.; Liang, G.; Li, R.; Wang, S.; Alnouri, M. W.; Bentsen, M.; Kuenne, C.; Guenther, S.; Yan, Y.; Li, Y. et al.; Wettschureck, N.; Offermanns, S.: Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Yoshida, T.; Yoshida, S.; Inukai, K.; Kato, K.; Yura, Y.; Hattori, T.; Taki, K.; Enomoto, A.; Ohashi, K.; Okumura, T. et al.; Ouchi, N.; Kawase, H.; Wettschureck, N.; Offermanns, S.; Murohara, T.; Takefuji, M.: ALPK2 prevents cardiac diastolic dysfunction in heart failure with preserved ejection fraction. FASEB JOURNAL 38 (22), e70192 (2024)

Alnouri, M. W.; Roquid, K. A.; Bonnavion, R.; Cho, H.; Heering, J.; Kwon, J.; Jaeger, Y.; Wang, S.; Guenther, S.; Wettschureck, N. et al.; Geisslingerb, G.; Gurke, R.; Mueller, C. E.; Proschak, E.; Offermanns, S.: SPMs exert anti- inflammatory and pro- resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (41), e2407130121 (2024)

Yoshida, S.; Yoshida, T.; Inukai, K.; Kato, K.; Yura, Y.; Hattori, T.; Enomoto, A.; Ohashi, K.; Okumura, T.; Ouchi, N. et al.; Kawase, H.; Wettschureck, N.; Offermanns, S.; Murohara, T.; Takefuji, M.: Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion. NATURE COMMUNICATIONS 15 (1), 7638 (2024)

Peng, Y.; Du, J.; Li, R.; Guenther, S.; Wettschureck, N.; Offermanns, S.; Wang, Y.; Schneider, A.; Braun, T.: RhoA-mediated G₁₂-G₁₃ signaling maintains muscle stem cell quiescence and prevents stem cell loss. CELL DISCOVERY 10 (1), 76 (2024)

Tamiato, A.; Tombor, L. S.; Fischer, A.; Muhly-Reinholz, M.; Vanicek, L. R.; Togru, B. N.; Neitz, J.; Glaser, S. F.; Merten, M.; Morales, D. R. et al.; Kwon, J.; Klatt, S.; Schumacher, B.; Guenther, S.; Abplanalp, W. T.; John, D.; Fleming, I.; Wettschureck, N.; Dimmeler, S.; Luxaen, G.: Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis. CIRCULATION RESEARCH 134 (10), pp. 1240 - 1255 (2024)

Wang, T.; Shao, J.; Shamit, K.; Alnouri, M. W.; Carvalho, J.; Guenther, S.; Krasel , C.; Murphy, K. T.; Buenemann, M.; Offermanns, S. et al.; Wettschureck, N.: Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction. CIRCULATION RESEARCH 134 (10), pp. 1259 - 1275 (2024)

Kurz, M.; Ulrich, M.; Bittner, A.; Scharf, M. M.; Shao, J.; Wallenstein, I.; Lemoine, H.; Wettschureck, N.; Kolb, P.; Buenemann, M.: EP4 Receptor Conformation Sensor Suited for Ligand Screening and Imaging of Extracellular Prostaglandins. MOLECULAR PHARMACOLOGY 104 (3), pp. 80 - 91 (2023)

Li, R.; Shao, J.; Jin, Y. J.; Haruya, K.; Ong, Y. T.; Troidl, K.; Quan, Q.; Wang, L.; Bonnavion, R.; Wietelmann, A. et al.; Helmbacher , F.; Potente, M.; Graumann, J.; Wettschureck, N.; Offermanns, S.: Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2. NATURE COMMUNICATIONS 14 (1), 1980 (2023)

Wang, S.; Wang, B.; Shi, Y.; Moeller, T.; Stegmeyer I, R.; Strilic, B.; Li, T.; Yuan, Z.; Wang, C.; Wettschureck, N. et al.; Vestweber, D.; Offermanns, S.: Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. BLOOD 140 (3), pp. 171 - 183 (2022)

Wang, S.; Wang, B.; Shi, Y.; Moller, T.; Stegmeyer, R. I.; Strilic, B.; Li, T.; Yuan, Z.; Wang, C.; Wettschureck, N. et al.; Vestweber, D.; Offermanns, S.: Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood (2022)

Gurusamy, M.; Tischner, D.; Shao, J.; Klatt, S.; Zukunft, S.; Bonnavion, R.; Guenther, S.; Siebenbrodt, K.; Kestner, R.-I.; Kuhlmann, T. et al.; Fleming, I.; Offermanns, S.; Wettschureck, N.: G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. NATURE COMMUNICATIONS 12 (1), 6798 (2021)

Ishihama, S.; Yoshida, S.; Yoshida, T.; Mori, Y.; Ouchi, N.; Eguchi, S.; Sakaguchi, T.; Tsuda, T.; Kato, K.; Shimizu, Y. et al.; Ohashi, K.; Okumura, T.; Bando, Y. K.; Yagyu, H.; Wettschureck, N.; Kubota, N.; Offermanns, S.; Kadowaki, T.; Murohara, T.; Takefuji, M.: LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia. FASEB JOURNAL 35 (12), e22048 (2021)

Jin, Y.-J.; Chennupati, R.; Li, R.; Liang, G.; Wang, S.; Iring, A.; Graumann, J.; Wettschureck, N.; Offermanns, S.: Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. JOURNAL OF CLINICAL INVESTIGATION 131 (21), e145734 (2021)

Demirel, E.; Arnold, C.; Garg, J.; Jaeger, M. A.; Sticht, C.; Li, R.; Kuk, H.; Wettschureck, N.; Hecker, M.; Korff, T.: RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells. CELLS 10 (7), 1748 (2021)

Xu, L.; Wettschureck, N.; Bai, Y.; Yuan, Z.; Wang, S.: Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice. JOURNAL OF HEPATOLOGY 75 (1), pp. 238 - 241 (2021)

Carvalho, J.; Chennupati, R.; Li, R.; Guenther, S.; Kaur, H.; Zhao, W.; Tonack, S.; Kurz, M.; Moesslein, N.; Buenemann, M. et al.; Offermanns, S.; Wettschureck, N.: Orphan G Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling. CIRCULATION 141 (14), pp. 1168 - 1183 (2020)

van den Bos, E.; Ambrosy, B.; Horsthemke, M.; Walbaum, S.; Bachg, A. C.; Wettschureck, N.; Innamorati, G.; Wilkie, T. M.; Hanley, P. J.: Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor?mediated chemotaxis. JOURNAL OF BIOLOGICAL CHEMISTRY 295 (22), pp. 7726 - 7742 (2020)

Wang, S.; Cao, S.; Arhatte, M.; Li, D.; Shi, Y.; Kurz, S.; Hu, J.; Wang, L.; Shao, J.; Atzberger, A. et al.; Wang, Z.; Wang, C.; Zang, W.; Fleming, I.; Wettschureck, N.; Honore, E.; Offermanns, S.: Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. NATURE COMMUNICATIONS 11 (1) (2020)