Publications of IMPRS students

Karger, A.; Mansouri, S.; Leisegang , M. S.; Weigert, A.; Guenther, S.; Kuenne, C.; Wittig , I.; Zukunft , S.; Klatt , S.; Aliraj , B. et al.; Klotz V , L.; Winter , H.; Mahavadi, P.; Fleming , I.; Ruppert , C.; Witte , B.; Alkoudmani , I.; Gattenloehner, S.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth. EMBO JOURNAL (2023)

Rogel-Ayala, D.; Munoz-Medina , J. E.; Vicente-Juarez , V. D.; Grether-Gonzalez, P.; Morales-Barquet , D. A.; Martinez-Garcia , A. d. J.; Echaniz-Aviles , M. O. L.; Sevilla-Montoya , R.; Martinez-Juarez , A.; Artega-Vazquez , J. et al.; Angeles-Martinez , J.; Vargas-Alarcon , G.; Hidalgo-Bravo , A.; Monroy-Munoz , I. E.: Association of the EPAS1 rs7557402 Polymorphism with Hemodynamically Significant Patent Ductus Arteriosus Closure Failure in Premature Newborns under Pharmacological Treatment with Ibuprofen. DIAGNOSTICS 13 (15), 2558 (2023)

Belapurkar, R.; Pfisterer, M.; Dreute, J.; Werner, S.; Zukunft, S.; Fleming, I.; Kracht , M.; Schmitz , M. L.: A transient increase of HIF-1alpha during the G1 phase (G1-HIF) ensures cell survival under nutritional stress. Cell death & disease 14 (7) (2023)

Zheng, X.; Sarode, P.; Weigert , A.; Turkowski, K.; Chelladurai, P.; Guenther, S.; Kuenne, C.; Winter , H.; Stenzinger, A.; Reu, S. et al.; Grimminger, F.; Stiewe, T.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization. CANCER RESEARCH 83 (14), pp. 2345 - 2357 (2023)

Barends, M.; Koller, N.; Scholz, C.; Duran, V.; Bosnjak, B.; Becker, J.; Doring, M.; Blees, H.; Forster, R.; Kalinke, U. et al.; Tampe, R.: Dynamic interactome of the MHC I peptide loading complex in human dendritic cells. Proceedings of the National Academy of Sciences of the United States of America 120 (25), e2219790120 (2023)

Barends, M.; Koller , N.; Schoelz , C.; Duran , V.; Bosnjak , B.; Becker, J.; Doering, M.; Blees, H.; Foerster, R.; Kalinke , U. et al.; Tampe , R.: Dynamic interactome of the MHC I peptide loading complex in human dendritic cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 120 (25), e2219790120 (2023)

Nayakanti, S. R.; Friedrich, A.; Sarode, P.; Jafari, L.; Maroli, G.; Boehm, M.; Bourgeois, A.; Grobs, Y.; Khassafi, F.; Kuenne, C. et al.; Guenther, S.; Dabral, S.; Wilhelm, J.; Weiss, A.; Wietelmann, A.; Kojonazarov, B.; Janssen, W.; Looso, M.; de Man, F.; Provencher, S.; Tello, K.; Seeger, W.; Bonnet, S.; Savai, R.; Schermuly, R.; Pullamsetti, S. S.: Targeting Wnt-ss-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling. CIRCULATION RESEARCH 132 (11), pp. 1468 - 1485 (2023)

Boezio, G. L. M.; Zhao, S.; Gollin, J.; Priya, R.; Mansingh, S.; Guenther, S.; Fukuda, N.; Gunawan, F.; Stainier, D. Y. R.: The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth. DISEASE MODELS & MECHANISMS 16 (5), dmm049571 (2023)

Rubio, K.; Romero-Olmedo, A. J.; Sarvari, P.; Swaminathan, G.; Ranvir, V. P.; Rogel-Ayala, D.; Cordero, J.; Guenther, S.; Mehta, A.; Bassaly, B. et al.; Braubach, P.; Wygrecka, M.; Gattenloehner, S.; Tresch, A.; Braun, T.; Dobreva, G.; Rivera, M. N.; Singh, I.; Graumann, J.; Barreto, G.: Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer. THERANOSTICS 13 (8), pp. 2384 - 2407 (2023)

Li, R.; Shao, J.; Jin, Y. J.; Haruya, K.; Ong, Y. T.; Troidl, K.; Quan, Q.; Wang, L.; Bonnavion, R.; Wietelmann, A. et al.; Helmbacher , F.; Potente, M.; Graumann, J.; Wettschureck, N.; Offermanns, S.: Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2. NATURE COMMUNICATIONS 14 (1), 1980 (2023)

Kennel, K. B.; Bozlar, M.; De Valk, A. F.; Greten, F. R.: Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity. CLINICAL CANCER RESEARCH 29 (6), pp. 1009 - 1016 (2023)

Aslan, G. S.; Jae, N.; Manavski, Y.; Fouani, Y.; Shumliakivska, M.; Kettenhausen, L.; Kirchhof, L.; Guenther, S.; Fischer, A.; Luxan, G. et al.; Dimmeler, S.: Malat1 deficiency prevents neonatal heart regeneration by inducing cardiomyocyte binucleation. JCI INSIGHT 8 (5), e162124 (2023)

Bi, R.; Yin, Q.; Li, H.; Yang, X.; Wang, Y.; Li, Q.; Fang, H.; Li, P.; Lyu, P.; Fan, Y. et al.; Ying, B.; Zhu, S.: A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury. NATURE COMMUNICATIONS 14 (1), 830 (2023)

Warwick, T.; Buchmann, G. K.; Pflueger-Mueller, B.; Spaeth, M.; Schuermann, C.; Abplanalp, W.; Tombor, L.; John, D.; Weigert, A.; Leo-Hansmann, M. et al.; Dimmeler, S.; Brandes, R. P.: Acute injury to the mouse carotid artery provokes a distinct healing response. FRONTIERS IN PHYSIOLOGY 14, 1125864 (2023)

Nakajima, H.; Ishikawa, H.; Yamamoto, T.; Chiba, A.; Fukui, H.; Sako, K.; Fukumoto, M.; Mattonet, K.; Kwon, H.-B.; Hui, S. P. et al.; Dobreva, G. D.; Kikuchi, K.; Helker, C. S. M.; Stainier, D. Y. R.; Mochizuki, N.: Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. DEVELOPMENTAL CELL 58 (3), pp. 224 - + (2023)

Boos, F.; Oo, J. A.; Warwick, T.; Guenther, S.; Ponce, J. I.; Lopez, M.; Rafii, D.; Buchmann, G.; Pham, M. D.; Msheik, Z. S. et al.; Li, T.; Seredinski, S.; Haydar, S.; Kashefiolasl, S.; Plate, K. H.; Behr, R.; Mietsch, M.; Krishnan, J.; Pullamsetti, S. S.; Bibli, S.-I.; Hinkel, R.; Baker, A. H.; Boon, R. A.; Schulz, M. H.; Wittig, I.; Miller Jr., F. J.; Brandes, R. P.; Leisegang, M. S.: The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. BASIC RESEARCH IN CARDIOLOGY 118 (1), 5 (2023)

Nakayama, A.; Roquid, K. A.; Iring, A.; Strilic, B.; Guenther, S.; Chen, M.; Weinstein, L. S.; Offermanns, S.: Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth. JOURNAL OF EXPERIMENTAL MEDICINE 220 (1), e20211628 (2023)

Wu, F.; Li, X.; Looso, M.; Liu, H.; Ding, D.; Guenther, S.; Kuenne, C.; Liu, S.; Weissmann, N.; Boettger, T. et al.; Atzberger, A.; Kolahian, S.; Renz, H.; Offermanns, S.; Gaertner, U.; Potente, M.; Zhou, Y.; Yuan, X.; Braun, T.: Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. NATURE GENETICS (2023; 55(1)), pp. 100 - 111 (2023)

Cattaneo, P.; Hayes, M. G. B.; Baumgarten, N.; Hecker, D.; Peruzzo, S.; Aslan, G. S.; Kunderfranco, P.; Larcher, V.; Zhang, L.; Contu, R. et al.; Fonseca, G.; Spinozzi, S.; Chen, J.; Condorelli, G.; Dimmeler, S.; Schulz, M. H.; Heinz, S.; Guimaraes-Camboa, N.; Evans, S. M.: DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal. NATURE COMMUNICATIONS 13 (1), 7444 (2022)

Lopez, M.; Malacarne, P. F.; Ramanujam, D. P.; Warwick, T.; Mueller, N.; Hu, J.; Dewenter, M.; Weigert, A.; Guenther, S.; Gilsbach, R. et al.; Engelhardt, S.; Brandes, R. P.; Rezende, F.: Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling. FRONTIERS IN PHYSIOLOGY 13, 1056369 (2022)

Jiang, Z.; El-Brolosy, M. A.; Serobyan, V.; Welker, J. M.; Retzer, N.; Dooley, C. M.; Jakutis, G.; Juan, T.; Fukuda, N.; Maischein, H.-M. et al.; Balciunas, D.; Stainier, D. Y. R.: Parental mutations influence wild-type offspring via transcriptional adaptation. SCIENCE ADVANCES 8 (47), eabj2029 (2022)

Oo, J. A.; Palfi, K.; Warwick, T.; Wittig, I.; Prieto-Garcia, C.; Matkovic, V.; Tomaskovic, I.; Boos, F.; Ponce, J. I.; Teichmann, T. et al.; Petriukov, K.; Haydar, S.; Maegdefessel, L.; Wu, Z.; Minh Pham, D.; Krishnan, J.; Baker, A. H.; Guenther, S.; Ulrich, H. D.; Dikic, I.; Leisegang, M. S.; Brandes, R. P.: Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2. CELL REPORTS 41 (7), e111670 (2022)

Zhang, T.; Kuenne, C.; Ding, D.; Guenther, S.; Guo, X.; Zhou, Y.; Yuan, X.; Braun, T.: Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells. NATURE COMMUNICATIONS 13 (1), 6907 (2022)

Leisegang, M. S.; Bains, J. K.; Seredinski, S.; Oo, J. A.; Krause, N. M.; Kuo, C.-C.; Guenther, S.; Cetin, N. S.; Warwick, T.; Cao, C. et al.; Boos, F.; Ponce, J. I.; Haydar, S.; Bednarz, R.; Valasarajan, C.; Fuhrmann, D. C.; Preussner, J.; Looso, M.; Pullamsetti, S. S.; Schulz, M. H.; Jonker, H. R. A.; Richter, C.; Rezende, F.; Gilsbach, R.; Pflueger-Mueller, B.; Wittig, I.; Grummt, I.; Ribarska, T.; Costa, I. G.; Schwalbe, H.; Brandes, R. P.: HIF1 alpha-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex. NATURE COMMUNICATIONS 13 (1), 6563 (2022)

Weigert, A.; Zheng, X.; Nenzel, A.; Turkowski, K.; Guenther, S.; Strack, E.; Sirait-Fischer, E.; Elwakeel, E.; Kur, I. M.; Nikam, V. S. et al.; Valasarajan, C.; Winter, H.; Wissgott, A.; Voswinkel, R.; Grimminger, F.; Brune, B.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system. NATURE COMMUNICATIONS 13 (1), 6078 (2022)