Publications of IMPRS students

Herrle, N.; Malacarne, P. F.; Warwick, T.; Cabrera-Orefice, A.; Chen, Y.; Gheisari, M.; Chatterjee, S.; Leisegang, M. S.; Sarakpi, T.; Wionski, S. et al.; Lopez, M.; Kader, C.; Teichmann, T.; Drekolia, M.-K.; Koch, I.; Kessler, M.; Klein, S.; Erhard Uschner, F.; Trebicka, J.; Brunst, S.; Proschak, E.; Gunther, S.; Rosas-Lemus, M.; Baumgarten, N.; Klatt, S.; Speer, T.; Bibli, S.-I.; Segarra, M.; Acker-Palmer, A.; Wagner, J. U. G.; Wittig, I.; Dimmeler, S.; Schulz, M. H.; Richards, J. B.; Gilsbach, R.; Denton, T. T.; Fleming, I.; Hannibal, L.; Brandes, R. P.; Rezende, F.: The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells. EMBO JOURNAL (2025)

Yilian, W.; Dierickx, P.: Circadian transcriptional repressors REV-ERB α/β and E4BP4 regulate cardiac function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 208 (2025)

Yin, Q.; Christelle, L.; Boettger, T.; Braun, T.: Enlargement of the muscle stem cell pool in linc-MYH-deficient mice does not prevent sarcopenia during aging. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 13, 1667437 (2025)

Majumdar, S.; Bammidi, L. S.; Naik, H. C.; Manhas, A.; Baro, R.; Kalita, A.; Naskar, A. J.; Nidharshan, S.; Bariha, G. S.; Notani, D. et al.; Gayen, S.: Xist upstream deletion leads to dysregulation of Xist and autosomal gene expression. GENOME RESEARCH 35 (9), pp. 1992 - 2010 (2025)

Shao, J.; Kwon, J.; Wang, T.; Guenther, S.; Tombor, L. S.; Warwick, T.; Shaheryar, Z.; Brandes, R. P.; Dimmeler, S.; Wenzel, J. et al.; Offermanns, S.; Schwaninger, M.; Wettschureck, N.: Orphan receptor GPR153 facilitates vascular damage responses by modulating cAMP levels, YAP/TAZ signaling, and NF-κB activation. NATURE COMMUNICATIONS 16 (1), 6232 (2025)

Rodriguez-Pulido, M.; Sanz, M. A.; Camacho, L.; Ramos, R.; Saiz, M.: Dicer is cleaved by the Leader protease encoded by foot-and-mouth disease virus to promote infection in mammalian cells. SCIENCE ADVANCES 11 (27), eadt3751 (2025)

Falcucci, L.; Dooley, C. M.; Adamoski, D.; Juan, T.; Martinez, J.; Georgieva, A. M.; Mamchaoui, K.; Cirzi, C.; Stainier, D. Y. R.: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy. NATURE (639(8054)), pp. 493 - 502 (2025)

Nawn, D.; Hassan, S. S.; Hromic-Jahjefendic, A.; Bhattacharya, T.; Basu, P.; Redwan, E. M.; Barh, D.; Andrade, B. S.; Aljabali, A. A.; Serrano-Aroca, A. et al.; Lundstrom, K.; Tambuwala, M. M.; Uversky, V. N.: Molecular genomic insights into melanoma associated proteins PRAME and BAP1. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), pp. 674 - 682 (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), pp. 674 - 682 (2025)

Kwon, J.; Haruya, K.; Mattonet, K.; Guenther, S.; Hahnefeld, L.; Shamsara, J.; Heering, J.; Kurz, M.; Kirchhofer, S.; Krasel, C. et al.; Ulrich, M.; Persechino, M.; Murthy, S.; Orlandi, C.; Sadik, C. D.; Geisslinger, G.; Buenemann, M.; Kolb, P.; Offermanns, S.; Wettschureck, N.: Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling. NATURE COMMUNICATIONS 16 (1), 1448 (2025)

Juvik, B.; Falcucci, L.; Lundegaard, P. R.; Stainier, D. Y. R.: A new hypothesis to explain disease dominance. TRENDS IN GENETICS 41 (3), pp. 187 - 193 (2025)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, P. M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Teichmann, T.; Pflueger-Mueller, B.; Gimenez, V. M. M.; Sailer, F.; Dirks, H.; Zehr, S.; Warwick, T.; Brettner, F.; Munoz-Tello, P.; Zimmer, A. et al.; Tegeder, I.; Thomas, D.; Gurke, R.; Guenther, S.; Heering, J.; Proschak, E.; Geisslinger, G.; Bibli, I.-S.; zu Heringdorf, D. M.; Manucha, W.; Windbergs, M.; Knapp, S.; Weigert, A.; Leisegang, M. S.; Kojetin, D.; Brandes, R. P.: The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors. BRITISH JOURNAL OF PHARMACOLOGY (2024)

Prieto-Garcia, C.; Matkovic, V.; Mosler, T.; Li, C.; Liang, J.; Oo, J. A.; Haidle, F.; Macinkovic, I.; Cabrera-Orefice, A.; Berkane, R. et al.; Giuliani, G.; Xu, F.; Jacomin, A.-C.; Tomaskovic, I.; Basoglu, M.; Hoffmann, M. E.; Rathore, R.; Cetin, R.; Boutguetait, D.; Bozkurt, S.; Canas, M. C. H.; Keller, M.; Busam, J.; Shah, V. J.; Wittig, I.; Kaulich, M.; Beli, P.; Galej, W. P.; Ebersberger, I.; Wang, L.; Muench, C.; Stolz, A.; Brandes, R. P.; Tse, W. K. F.; Eimer, S.; Stainier, D. Y. R.; Legewie, S.; Zarnack, K.; Mueller-McNicoll, M.; Dikic, I.: Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy. SCIENCE 386 (6723), pp. 768 - 776 (2024)

Alnouri, M. W.; Roquid, K. A.; Bonnavion, R.; Cho, H.; Heering, J.; Kwon, J.; Jaeger, Y.; Wang, S.; Guenther, S.; Wettschureck, N. et al.; Geisslingerb, G.; Gurke, R.; Mueller, C. E.; Proschak, E.; Offermanns, S.: SPMs exert anti- inflammatory and pro- resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (41), e2407130121 (2024)

Weiss, L. M.; Warwick, T.; Zehr, S.; Guenther, S.; Wolf, S.; Schmachtel, T.; Ponce, J. I.; Palfi, K.; Teichmann, T.; Schneider, A. et al.; Stoetzel, J.; Knapp, S.; Weigert, A.; Savai, R.; Rieger, M. A.; Oellerich, T.; Wittig, I.; Oo, J. A.; Brandes, R. P.; Leisegang, M. S.: RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions. COMMUNICATIONS BIOLOGY 7 (1), 1131 (2024)

Ozaki, K.; Kato, R.; Yasuhara, T.; Uchihara, Y.; Hirakawa, M.; Abe, Y.; Shibata, H.; Kawabata-Iwakawa, R.; Shakayeva, A.; Kot, P. et al.; Miyagawa, K.; Suzuki, K.; Matsuda, N.; Shibata, A.; Yamauchi, M.: Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks. SCIENTIFIC REPORTS 14 (1), 18455 (2024)

Maroli, G.; Scha, A.; Guenther, S.; -Gonzalez, C. G.; Rupp, S.; Schlierbach, H.; Chen, Y.; Graumann, J.; Wietelmann, A.; Kim, J. et al.; Braun, T.: Inhibition of autophagy prevents cardiac dysfunction at early stages of cardiomyopathy in Bag3-deficient hearts. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 193, pp. 53 - 66 (2024)

Peng, Y.; Du, J.; Li, R.; Guenther, S.; Wettschureck, N.; Offermanns, S.; Wang, Y.; Schneider, A.; Braun, T.: RhoA-mediated G₁₂-G₁₃ signaling maintains muscle stem cell quiescence and prevents stem cell loss. CELL DISCOVERY 10 (1), 76 (2024)

Gentile, A.; Albu, P. M.; Xu, Y.; Mortazavi , N.; da Silva, A.; Stainier, D. Y. R.; Gunawan, F.: Mechanical forces remodel the cardiac extracellular matrix during zebrafish development. DEVELOPMENT 151 (13), dev202310 (2024)

Kumari, P.; Tarighi, S.; Fuchshuber, E.; Li, L.; Fernandez-Duran, I.; Wang, M.; Ayoson, J.; Castello-Garcia, J. M.; Gamez-Garcia, A.; Espinosa-Alcantud, M. et al.; Sreenivasan, K.; Guenther, S.; Olivella, M.; Savai, R.; Yue, S.; Vaquero, A.; Braun, T.; Ianni, A.: SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (25), e2409269121 (2024)

Zhu, Y.; Ackers-Johnson, M.; Shanmugam, M. K.; Pakkiri, L. S.; Drum, C. L.; Chen, Y.; Kim, J.; Paltzer, W. G.; Mahmoud, A. I.; Tan, W. L. W. et al.; Lee, M. C. J.; Jiang, J.; Luu, D. A. T.; Ng, S. L.; Li, P. Y. Q.; Wang, A.; Qi, R.; Ong, G. J. X.; Ng, T. Y.; Haigh, J. J.; Tiang, Z.; Richards, A. M.; Foo, R. S. Y.: Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation. CIRCULATION 149 (23), pp. 1833 - 1851 (2024)

Gauvrit, S.; Zhao, S.; Rothbauer, U.; Stainier, D. Y. R.: A β-catenin chromobody-based probe highlights endothelial maturation during vascular morphogenesis in vivo. DEVELOPMENT 151 (11), dev202122 (2024)

Brunnberg, J.; Barends, M.; Fruehschulz, S.; Winter, C.; Battin, C.; de Wet, B.; Cole, D. K.; Steinberger, P.; Tampe, R.: Dual role of the peptide- loading complex as proofreader and limiter of MHC- I presentation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (22), e2321600121 (2024)