Publications of IMPRS students

Malacarne, P. F.; Lopez, M.; Chatterjee, S.; Herrle, N.; Weiss, L.; Gunther, S.; Osborne, T.; Glaubitz, C.; Schmid, T.; Kurrle, N. et al.; Schnutgen, F.; Lutjohann, D.; Brandes, R. P.; Rezende, F.: Endothelial cytochrome P450-derived cholesterol limits angiogenesis. REDOX BIOLOGY 95, 104289 (2026)

Walter, J.; Kuenne, C.; Knoppik, N.; Goymann, P.; Looso, M.: FRED enables standardized FAIR metadata generation and management for omics research. SCIENTIFIC REPORTS 16 (1), 23202 (2026)

Panel, N.; Vo, D. D.; Hubner, H.; Deluigi, M.; Pach, S.; Belair, F.; Weikert, D.; Klenk, C.; Hilge, M.; Shiva, N. et al.; Brochu, I.; Longpre, J.-M.; Ballgren, F.; Saleh, A.; Hu, H.; Kapla, J.; Kampen, S.; Cabeza de Vaca, I.; Kihlberg, J.; Wettschureck, N.; Sarret, P.; Pluckthun, A.; Gmeiner, P.; Carlsson, J.: Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity. NATURE COMMUNICATIONS 17 (1), 6970 (2026)

Lam, F.; Warwick, T.; Oo, J. A.; Kruger, A. Y.; Kreis, N.-N.; Diagel, A.; Ponce, J. I.; Tirunagari, P.; Bayer, M. E.; Nonn, O. et al.; Dechend, R.; Walther, T.; Boon, R. A.; Baker, A. H.; Gunther, S.; Wittig, I.; Chen, Z.; Muller-McNicoll, M.; Louwen, F.; Brandes, R. P.; Leisegang, M. S.: LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing. MOLECULAR THERAPY 34 (7), pp. 4323 - 4338 (2026)

Shiva, N.; Kawase, H.; Einsiedel, J.; Kwon, J.; Kumar, S.; Shao, J.; Du, Z.; Kubin, N.; Shimari, M.; Gunther, S. et al.; Li, T.; Dierickx, P.; Sossalla, S.; Offermanns, S.; Gmeiner, P.; Wettschureck, N.: Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models. SCIENCE TRANSLATIONAL MEDICINE 18 (856), eaea9877 (2026)

Schultheis, H.; Detleffsen, J.; Wiegandt, R.; Bentsen, M.; Alayoubi, Y.; Valente, G.; Kessler, M. F.; Bruns, B.; Mirza, D.; Usanayo, A. et al.; Mueller, K.; Walter, J.; Goymann, P.; Hobein, M.; Kuenne, C.; Looso, M.: SC-framework: A robust and FAIR semi-interactive environment for single-cell resolution datasets. ISCIENCE 29 (7), 116631 (2026)

Kawase, H.; Liu, S.; Kurz, S.; Bengelsdorff, V.; Bonnavion, R.; Jin, Y.-J.; Roquid, K. A.; Cho, H.; Liang, G.; Banicevic, M. et al.; Shiva, N.; Yunes-Leites, P. S.; Gunther, S.; Tombor, L.; Dimmeler, S.; Looso, M.; Mattonet, K.; Wettschureck, N.; Muller, U. C.; Offermanns, S.: Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis. SCIENCE ADVANCES 12 (21), eaeh0301 (2026)

Dizdarevic, S.; Timofeev, O.; Kazdal, D.; Pullamsetti, S. S.; Sotillo, R.; Loges, S.; Kobold, S.; Stenzinger, A.; Stiewe, T.; Savai, R.: Tumor microenvironment evolution in lung cancer: Spatio-temporal dynamics and clinical implications. SEMINARS IN CANCER BIOLOGY 123, pp. 1 - 26 (2026)

Mintcheva, J.; Tseng, T.-L.; Goumenaki, P.; Neuschulz, A.; Senoussi, A.; Lelek, S.; Lim, K. L.; Ming, Z.; Schafer, R.; Hnatiuk, A. et al.; Ninov, N.; Beisaw, A.; McGrail, M.; Lai, S.-L. B.; Panakova, D.; Stainier, D. Y. R.; Junker, J. P.: In vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart. NATURE COMMUNICATIONS 17 (1), 4073 (2026)

Tarasco, M.; Juan, T.; Alayoubi, Y.; Kulkarni, R.; Schumann, A.; da Silva, A. R.; Albu, M.; Dwari, M.; Dlnija, M.; Gunther, S. et al.; Looso, M.; Stainier, D. Y. R.: Time-resolved single-cell transcriptomics maps zebrafish heart development. CELL REPORTS 45 (4), 117249 (2026)

Carpenter, B. J.; Lecacheur, M.; Mangold, Y. N.; Cui, K.; Gunther, S.; Vermunt, M. W.; Dierickx, P.: NAD+ controls circadian rhythmicity during cardiac aging. COMMUNICATIONS BIOLOGY 9 (1), 476 (2026)

Niu, Z.; Liu, C.; Fan, Y.; Gu, L.: Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 123 (11), e2533687123 (2026)

Dizdarevic, S.; Wiegandt, R.; Weigert, A.; Stiewe, T.; Eul, B.; Guenther, S.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Looso, M. et al.; Turkowski, K.; Savai, R.: Divergent CD45+ immune landscapes shape the lung tumor microenvironment. FRONTIERS IN IMMUNOLOGY 17, 1765833 (2026)

Herrle, N.; Malacarne, P. F.; Warwick, T.; Cabrera-Orefice, A.; Chen, Y.; Gheisari, M.; Chatterjee, S.; Leisegang, M. S.; Sarakpi, T.; Wionski, S. et al.; Lopez, M.; Kader, C.; Teichmann, T.; Drekolia, M.-K.; Koch, I.; Kessler, M.; Klein, S.; Erhard Uschner, F.; Trebicka, J.; Brunst, S.; Proschak, E.; Gunther, S.; Rosas-Lemus, M.; Baumgarten, N.; Klatt, S.; Speer, T.; Bibli, S.-I.; Segarra, M.; Acker-Palmer, A.; Wagner, J. U. G.; Wittig, I.; Dimmeler, S.; Schulz, M. H.; Richards, J. B.; Gilsbach, R.; Denton, T. T.; Fleming, I.; Hannibal, L.; Brandes, R. P.; Rezende, F.: The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells. EMBO JOURNAL 45 (3), pp. 820 - 855 (2026)

Drekolia, M.-K.; Mettner, J.; Wang, D.; Lagos, F. D.; Koch, C.; Hecker, D.; Eresch, J.; Mao, Y.; Bahr, M.; Weichenhan, D. et al.; Cordero, J.; Wittig, J.; Zhang, B.; Cui, H.; Li, X.; Oo, J. A.; Weigert, A.; Siragusa, M.; Klatt, S.; Fleming, I.; Gunther, S.; Looso, M.; Brandes, R. P.; Langer, H. F.; Papapetropoulos, A.; Singhal, M.; Schulz, M. H.; Plass, C.; Heineke, J.; Dobreva, G.; Hu, J.; Bibli, S.-I.: Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation. CELL METABOLISM 38 (1) (2026)

Bi, R.; Yang, X.; Li, H.; Zhan, Y.; Yin, Q.; Fang, H.; Wang, Z.; Ying, B.; Yu, H.; Zhu, S.: Integrin inhibition facilitates fibrocartilaginous transformation in connective tissue in osteoarthritis. SCIENCE ADVANCES 12 (1), eady4112 (2026)

Herrle, N.; Malacarne, P. F.; Warwick, T.; Cabrera-Orefice, A.; Chen, Y.; Gheisari, M.; Chatterjee, S.; Leisegang, M. S.; Sarakpi, T.; Wionski, S. et al.; Lopez, M.; Kader, C.; Teichmann, T.; Drekolia, M.-K.; Koch, I.; Kessler, M.; Klein, S.; Erhard Uschner, F.; Trebicka, J.; Brunst, S.; Proschak, E.; Gunther, S.; Rosas-Lemus, M.; Baumgarten, N.; Klatt, S.; Speer, T.; Bibli, S.-I.; Segarra, M.; Acker-Palmer, A.; Wagner, J. U. G.; Wittig, I.; Dimmeler, S.; Schulz, M. H.; Richards, J. B.; Gilsbach, R.; Denton, T. T.; Fleming, I.; Hannibal, L.; Brandes, R. P.; Rezende, F.: The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells. EMBO JOURNAL (2025)

Yilian, W.; Dierickx, P.: Circadian transcriptional repressors REV-ERB α/β and E4BP4 regulate cardiac function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 208 (2025)

Yin, Q.; Christelle, L.; Boettger, T.; Braun, T.: Enlargement of the muscle stem cell pool in linc-MYH-deficient mice does not prevent sarcopenia during aging. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 13, 1667437 (2025)

Majumdar, S.; Bammidi, L. S.; Naik, H. C.; Manhas, A.; Baro, R.; Kalita, A.; Naskar, A. J.; Nidharshan, S.; Bariha, G. S.; Notani, D. et al.; Gayen, S.: Xist upstream deletion leads to dysregulation of Xist and autosomal gene expression. GENOME RESEARCH 35 (9), pp. 1992 - 2010 (2025)

Shao, J.; Kwon, J.; Wang, T.; Guenther, S.; Tombor, L. S.; Warwick, T.; Shaheryar, Z.; Brandes, R. P.; Dimmeler, S.; Wenzel, J. et al.; Offermanns, S.; Schwaninger, M.; Wettschureck, N.: Orphan receptor GPR153 facilitates vascular damage responses by modulating cAMP levels, YAP/TAZ signaling, and NF-κB activation. NATURE COMMUNICATIONS 16 (1), 6232 (2025)

Rodriguez-Pulido, M.; Sanz, M. A.; Camacho, L.; Ramos, R.; Saiz, M.: Dicer is cleaved by the Leader protease encoded by foot-and-mouth disease virus to promote infection in mammalian cells. SCIENCE ADVANCES 11 (27), eadt3751 (2025)

Falcucci, L.; Dooley, C. M.; Adamoski, D.; Juan, T.; Martinez, J.; Georgieva, A. M.; Mamchaoui, K.; Cirzi, C.; Stainier, D. Y. R.: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy. NATURE (639(8054)), pp. 493 - 502 (2025)

Nawn, D.; Hassan, S. S.; Hromic-Jahjefendic, A.; Bhattacharya, T.; Basu, P.; Redwan, E. M.; Barh, D.; Andrade, B. S.; Aljabali, A. A.; Serrano-Aroca, A. et al.; Lundstrom, K.; Tambuwala, M. M.; Uversky, V. N.: Molecular genomic insights into melanoma associated proteins PRAME and BAP1. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), pp. 674 - 682 (2025)