Publications of IMPRS students

Kawase, H.; Liu, S.; Kurz, S.; Bengelsdorff, V.; Bonnavion, R.; Jin, Y.-J.; Roquid, K. A.; Cho, H.; Liang, G.; Banicevic, M. et al.; Shiva, N.; Yunes-Leites, P. S.; Gunther, S.; Tombor, L.; Dimmeler, S.; Looso, M.; Mattonet, K.; Wettschureck, N.; Muller, U. C.; Offermanns, S.: Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis. SCIENCE ADVANCES 12 (21), eaeh0301 (2026)

Dizdarevic, S.; Timofeev, O.; Kazdal, D.; Pullamsetti, S. S.; Sotillo, R.; Loges, S.; Kobold, S.; Stenzinger, A.; Stiewe, T.; Savai, R.: Tumor microenvironment evolution in lung cancer: Spatio-temporal dynamics and clinical implications. SEMINARS IN CANCER BIOLOGY 123, pp. 1 - 26 (2026)

Mintcheva, J.; Tseng, T.-L.; Goumenaki, P.; Neuschulz, A.; Senoussi, A.; Lelek, S.; Lim, K. L.; Ming, Z.; Schafer, R.; Hnatiuk, A. et al.; Ninov, N.; Beisaw, A.; McGrail, M.; Lai, S.-L. B.; Panakova, D.; Stainier, D. Y. R.; Junker, J. P.: In vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart. NATURE COMMUNICATIONS 17 (1), 4073 (2026)

Tarasco, M.; Juan, T.; Alayoubi, Y.; Kulkarni, R.; Schumann, A.; da Silva, A. R.; Albu, M.; Dwari, M.; Dlnija, M.; Gunther, S. et al.; Looso, M.; Stainier, D. Y. R.: Time-resolved single-cell transcriptomics maps zebrafish heart development. CELL REPORTS 45 (4), 117249 (2026)

Carpenter, B. J.; Lecacheur, M.; Mangold, Y. N.; Cui, K.; Gunther, S.; Vermunt, M. W.; Dierickx, P.: NAD+ controls circadian rhythmicity during cardiac aging. COMMUNICATIONS BIOLOGY 9 (1), 476 (2026)

Niu, Z.; Liu, C.; Fan, Y.; Gu, L.: Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 123 (11), e2533687123 (2026)

Dizdarevic, S.; Wiegandt, R.; Weigert, A.; Stiewe, T.; Eul, B.; Guenther, S.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Looso, M. et al.; Turkowski, K.; Savai, R.: Divergent CD45+ immune landscapes shape the lung tumor microenvironment. FRONTIERS IN IMMUNOLOGY 17, 1765833 (2026)

Herrle, N.; Malacarne, P. F.; Warwick, T.; Cabrera-Orefice, A.; Chen, Y.; Gheisari, M.; Chatterjee, S.; Leisegang, M. S.; Sarakpi, T.; Wionski, S. et al.; Lopez, M.; Kader, C.; Teichmann, T.; Drekolia, M.-K.; Koch, I.; Kessler, M.; Klein, S.; Erhard Uschner, F.; Trebicka, J.; Brunst, S.; Proschak, E.; Gunther, S.; Rosas-Lemus, M.; Baumgarten, N.; Klatt, S.; Speer, T.; Bibli, S.-I.; Segarra, M.; Acker-Palmer, A.; Wagner, J. U. G.; Wittig, I.; Dimmeler, S.; Schulz, M. H.; Richards, J. B.; Gilsbach, R.; Denton, T. T.; Fleming, I.; Hannibal, L.; Brandes, R. P.; Rezende, F.: The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells. EMBO JOURNAL 45 (3), pp. 820 - 855 (2026)

Drekolia, M.-K.; Mettner, J.; Wang, D.; Lagos, F. D.; Koch, C.; Hecker, D.; Eresch, J.; Mao, Y.; Bahr, M.; Weichenhan, D. et al.; Cordero, J.; Wittig, J.; Zhang, B.; Cui, H.; Li, X.; Oo, J. A.; Weigert, A.; Siragusa, M.; Klatt, S.; Fleming, I.; Gunther, S.; Looso, M.; Brandes, R. P.; Langer, H. F.; Papapetropoulos, A.; Singhal, M.; Schulz, M. H.; Plass, C.; Heineke, J.; Dobreva, G.; Hu, J.; Bibli, S.-I.: Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation. CELL METABOLISM 38 (1) (2026)

Bi, R.; Yang, X.; Li, H.; Zhan, Y.; Yin, Q.; Fang, H.; Wang, Z.; Ying, B.; Yu, H.; Zhu, S.: Integrin inhibition facilitates fibrocartilaginous transformation in connective tissue in osteoarthritis. SCIENCE ADVANCES 12 (1), eady4112 (2026)

Herrle, N.; Malacarne, P. F.; Warwick, T.; Cabrera-Orefice, A.; Chen, Y.; Gheisari, M.; Chatterjee, S.; Leisegang, M. S.; Sarakpi, T.; Wionski, S. et al.; Lopez, M.; Kader, C.; Teichmann, T.; Drekolia, M.-K.; Koch, I.; Kessler, M.; Klein, S.; Erhard Uschner, F.; Trebicka, J.; Brunst, S.; Proschak, E.; Gunther, S.; Rosas-Lemus, M.; Baumgarten, N.; Klatt, S.; Speer, T.; Bibli, S.-I.; Segarra, M.; Acker-Palmer, A.; Wagner, J. U. G.; Wittig, I.; Dimmeler, S.; Schulz, M. H.; Richards, J. B.; Gilsbach, R.; Denton, T. T.; Fleming, I.; Hannibal, L.; Brandes, R. P.; Rezende, F.: The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells. EMBO JOURNAL (2025)

Yilian, W.; Dierickx, P.: Circadian transcriptional repressors REV-ERB α/β and E4BP4 regulate cardiac function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 208 (2025)

Yin, Q.; Christelle, L.; Boettger, T.; Braun, T.: Enlargement of the muscle stem cell pool in linc-MYH-deficient mice does not prevent sarcopenia during aging. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 13, 1667437 (2025)

Majumdar, S.; Bammidi, L. S.; Naik, H. C.; Manhas, A.; Baro, R.; Kalita, A.; Naskar, A. J.; Nidharshan, S.; Bariha, G. S.; Notani, D. et al.; Gayen, S.: Xist upstream deletion leads to dysregulation of Xist and autosomal gene expression. GENOME RESEARCH 35 (9), pp. 1992 - 2010 (2025)

Shao, J.; Kwon, J.; Wang, T.; Guenther, S.; Tombor, L. S.; Warwick, T.; Shaheryar, Z.; Brandes, R. P.; Dimmeler, S.; Wenzel, J. et al.; Offermanns, S.; Schwaninger, M.; Wettschureck, N.: Orphan receptor GPR153 facilitates vascular damage responses by modulating cAMP levels, YAP/TAZ signaling, and NF-κB activation. NATURE COMMUNICATIONS 16 (1), 6232 (2025)

Rodriguez-Pulido, M.; Sanz, M. A.; Camacho, L.; Ramos, R.; Saiz, M.: Dicer is cleaved by the Leader protease encoded by foot-and-mouth disease virus to promote infection in mammalian cells. SCIENCE ADVANCES 11 (27), eadt3751 (2025)

Falcucci, L.; Dooley, C. M.; Adamoski, D.; Juan, T.; Martinez, J.; Georgieva, A. M.; Mamchaoui, K.; Cirzi, C.; Stainier, D. Y. R.: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy. NATURE (639(8054)), pp. 493 - 502 (2025)

Nawn, D.; Hassan, S. S.; Hromic-Jahjefendic, A.; Bhattacharya, T.; Basu, P.; Redwan, E. M.; Barh, D.; Andrade, B. S.; Aljabali, A. A.; Serrano-Aroca, A. et al.; Lundstrom, K.; Tambuwala, M. M.; Uversky, V. N.: Molecular genomic insights into melanoma associated proteins PRAME and BAP1. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), pp. 674 - 682 (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), pp. 674 - 682 (2025)

Kwon, J.; Haruya, K.; Mattonet, K.; Guenther, S.; Hahnefeld, L.; Shamsara, J.; Heering, J.; Kurz, M.; Kirchhofer, S.; Krasel, C. et al.; Ulrich, M.; Persechino, M.; Murthy, S.; Orlandi, C.; Sadik, C. D.; Geisslinger, G.; Buenemann, M.; Kolb, P.; Offermanns, S.; Wettschureck, N.: Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling. NATURE COMMUNICATIONS 16 (1), 1448 (2025)

Juvik, B.; Falcucci, L.; Lundegaard, P. R.; Stainier, D. Y. R.: A new hypothesis to explain disease dominance. TRENDS IN GENETICS 41 (3), pp. 187 - 193 (2025)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, P. M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Teichmann, T.; Pflueger-Mueller, B.; Gimenez, V. M. M.; Sailer, F.; Dirks, H.; Zehr, S.; Warwick, T.; Brettner, F.; Munoz-Tello, P.; Zimmer, A. et al.; Tegeder, I.; Thomas, D.; Gurke, R.; Guenther, S.; Heering, J.; Proschak, E.; Geisslinger, G.; Bibli, I.-S.; zu Heringdorf, D. M.; Manucha, W.; Windbergs, M.; Knapp, S.; Weigert, A.; Leisegang, M. S.; Kojetin, D.; Brandes, R. P.: The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors. BRITISH JOURNAL OF PHARMACOLOGY (2024)

Prieto-Garcia, C.; Matkovic, V.; Mosler, T.; Li, C.; Liang, J.; Oo, J. A.; Haidle, F.; Macinkovic, I.; Cabrera-Orefice, A.; Berkane, R. et al.; Giuliani, G.; Xu, F.; Jacomin, A.-C.; Tomaskovic, I.; Basoglu, M.; Hoffmann, M. E.; Rathore, R.; Cetin, R.; Boutguetait, D.; Bozkurt, S.; Canas, M. C. H.; Keller, M.; Busam, J.; Shah, V. J.; Wittig, I.; Kaulich, M.; Beli, P.; Galej, W. P.; Ebersberger, I.; Wang, L.; Muench, C.; Stolz, A.; Brandes, R. P.; Tse, W. K. F.; Eimer, S.; Stainier, D. Y. R.; Legewie, S.; Zarnack, K.; Mueller-McNicoll, M.; Dikic, I.: Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy. SCIENCE 386 (6723), pp. 768 - 776 (2024)