Publications of IMPRS students

Kennel, K. B.; Bozlar, M.; De Valk, A. F.; Greten, F. R.: Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity. CLINICAL CANCER RESEARCH 29 (6), pp. 1009 - 1016 (2023)

Aslan, G. S.; Jae, N.; Manavski, Y.; Fouani, Y.; Shumliakivska, M.; Kettenhausen, L.; Kirchhof, L.; Guenther, S.; Fischer, A.; Luxan, G. et al.; Dimmeler, S.: Malat1 deficiency prevents neonatal heart regeneration by inducing cardiomyocyte binucleation. JCI INSIGHT 8 (5), e162124 (2023)

Warwick, T.; Buchmann, G. K.; Pflueger-Mueller, B.; Spaeth, M.; Schuermann, C.; Abplanalp, W.; Tombor, L.; John, D.; Weigert, A.; Leo-Hansmann, M. et al.; Dimmeler, S.; Brandes, R. P.: Acute injury to the mouse carotid artery provokes a distinct healing response. FRONTIERS IN PHYSIOLOGY 14, 1125864 (2023)

Nakajima, H.; Ishikawa, H.; Yamamoto, T.; Chiba, A.; Fukui, H.; Sako, K.; Fukumoto, M.; Mattonet, K.; Kwon, H.-B.; Hui, S. P. et al.; Dobreva, G. D.; Kikuchi, K.; Helker, C. S. M.; Stainier, D. Y. R.; Mochizuki, N.: Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. DEVELOPMENTAL CELL 58 (3), pp. 224 - + (2023)

Boos, F.; Oo, J. A.; Warwick, T.; Guenther, S.; Ponce, J. I.; Lopez, M.; Rafii, D.; Buchmann, G.; Pham, M. D.; Msheik, Z. S. et al.; Li, T.; Seredinski, S.; Haydar, S.; Kashefiolasl, S.; Plate, K. H.; Behr, R.; Mietsch, M.; Krishnan, J.; Pullamsetti, S. S.; Bibli, S.-I.; Hinkel, R.; Baker, A. H.; Boon, R. A.; Schulz, M. H.; Wittig, I.; Miller Jr., F. J.; Brandes, R. P.; Leisegang, M. S.: The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. BASIC RESEARCH IN CARDIOLOGY 118 (1), 5 (2023)

Nakayama, A.; Roquid, K. A.; Iring, A.; Strilic, B.; Guenther, S.; Chen, M.; Weinstein, L. S.; Offermanns, S.: Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth. JOURNAL OF EXPERIMENTAL MEDICINE 220 (1), e20211628 (2023)

Wu, F.; Li, X.; Looso, M.; Liu, H.; Ding, D.; Guenther, S.; Kuenne, C.; Liu, S.; Weissmann, N.; Boettger, T. et al.; Atzberger, A.; Kolahian, S.; Renz, H.; Offermanns, S.; Gaertner, U.; Potente, M.; Zhou, Y.; Yuan, X.; Braun, T.: Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. NATURE GENETICS (2023; 55(1)), pp. 100 - 111 (2023)

Cattaneo, P.; Hayes, M. G. B.; Baumgarten, N.; Hecker, D.; Peruzzo, S.; Aslan, G. S.; Kunderfranco, P.; Larcher, V.; Zhang, L.; Contu, R. et al.; Fonseca, G.; Spinozzi, S.; Chen, J.; Condorelli, G.; Dimmeler, S.; Schulz, M. H.; Heinz, S.; Guimaraes-Camboa, N.; Evans, S. M.: DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal. NATURE COMMUNICATIONS 13 (1), 7444 (2022)

Lopez, M.; Malacarne, P. F.; Ramanujam, D. P.; Warwick, T.; Mueller, N.; Hu, J.; Dewenter, M.; Weigert, A.; Guenther, S.; Gilsbach, R. et al.; Engelhardt, S.; Brandes, R. P.; Rezende, F.: Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling. FRONTIERS IN PHYSIOLOGY 13, 1056369 (2022)

Jiang, Z.; El-Brolosy, M. A.; Serobyan, V.; Welker, J. M.; Retzer, N.; Dooley, C. M.; Jakutis, G.; Juan, T.; Fukuda, N.; Maischein, H.-M. et al.; Balciunas, D.; Stainier, D. Y. R.: Parental mutations influence wild-type offspring via transcriptional adaptation. SCIENCE ADVANCES 8 (47), eabj2029 (2022)

Oo, J. A.; Palfi, K.; Warwick, T.; Wittig, I.; Prieto-Garcia, C.; Matkovic, V.; Tomaskovic, I.; Boos, F.; Ponce, J. I.; Teichmann, T. et al.; Petriukov, K.; Haydar, S.; Maegdefessel, L.; Wu, Z.; Minh Pham, D.; Krishnan, J.; Baker, A. H.; Guenther, S.; Ulrich, H. D.; Dikic, I.; Leisegang, M. S.; Brandes, R. P.: Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2. CELL REPORTS 41 (7), e111670 (2022)

Zhang, T.; Kuenne, C.; Ding, D.; Guenther, S.; Guo, X.; Zhou, Y.; Yuan, X.; Braun, T.: Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells. NATURE COMMUNICATIONS 13 (1), 6907 (2022)

Leisegang, M. S.; Bains, J. K.; Seredinski, S.; Oo, J. A.; Krause, N. M.; Kuo, C.-C.; Guenther, S.; Cetin, N. S.; Warwick, T.; Cao, C. et al.; Boos, F.; Ponce, J. I.; Haydar, S.; Bednarz, R.; Valasarajan, C.; Fuhrmann, D. C.; Preussner, J.; Looso, M.; Pullamsetti, S. S.; Schulz, M. H.; Jonker, H. R. A.; Richter, C.; Rezende, F.; Gilsbach, R.; Pflueger-Mueller, B.; Wittig, I.; Grummt, I.; Ribarska, T.; Costa, I. G.; Schwalbe, H.; Brandes, R. P.: HIF1 alpha-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex. NATURE COMMUNICATIONS 13 (1), 6563 (2022)

Weigert, A.; Zheng, X.; Nenzel, A.; Turkowski, K.; Guenther, S.; Strack, E.; Sirait-Fischer, E.; Elwakeel, E.; Kur, I. M.; Nikam, V. S. et al.; Valasarajan, C.; Winter, H.; Wissgott, A.; Voswinkel, R.; Grimminger, F.; Brune, B.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system. NATURE COMMUNICATIONS 13 (1), 6078 (2022)

Garcia-Gonzalez, C.; Dieterich, C.; Maroli, G.; Wiesnet, M.; Wietelmann, A.; Li, X.; Yuan, X.; Graumann, J.; Stellos, K.; Kubin, T. et al.; Schneider, A.; Braun, T.: ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7. CIRCULATION RESEARCH 131 (7), pp. 580 - 597 (2022)

Mattonet, K.; Riemslagh, F. W.; Guenther, S.; Prummel, K. D.; Kesavan, G.; Hans, S.; Ebersberger, I.; Brand, M.; Burger, A.; Reischauer, S. et al.; Mosimann, C.; Stainier, D. Y. R.: Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2. SCIENCE ADVANCES 8 (35), eabn2082 (2022)

Selle, J.; Dinger, K.; Jentgen, V.; Zanetti, D.; Will, J.; Georgomanolis, T.; Vohlen, C.; Wilke, R.; Kojonazarov, B.; Klymenko, O. et al.; Mohr, J.; Koningsbruggen-Rietschel, S. v.; Rhodes, C. J.; Ulrich, A.; Hirani, D.; Nestler, T.; Odenthal, M.; Mahabir, E.; Nayakanti, S.; Dabral, S.; Wunderlich, T.; Priest, J.; Seeger, W.; Doetsch, J.; Pullamsetti, S. S.; Alcazar, M. A. A.: Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life. NATURE COMMUNICATIONS 13 (1), 4352 (2022)

Hu, B.; Lelek, S.; Spanjaard, B.; El-Sammak, H.; Simoes, M. G.; Mintcheva, J.; Aliee, H.; Schaefer, R.; Meyer, A. M.; Theis, F. et al.; Stainier, D. Y. R.; Panakova, D.; Junker, J. P.: Origin and function of activated fibroblast states during zebrafish heart regeneration. NATURE GENETICS (2022)

Georgieva, A. M.; Guo, X.; Bartkuhn, M.; Guenther, S.; Kuenne, C.; Smolka, C.; Atzberger, A.; Gaertner, U.; Mamchaoui, K.; Bober, E. et al.; Zhou, Y.; Yuan, X.; Braun, T.: Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression. NATURE COMMUNICATIONS 13 (1), 4184 (2022)

Xu, R.; Hoess, C.; Swiercz, J. M.; Brandt, D. T.; Lutz, V.; Petersen, N.; Li, R.; Zhao, D.; Oleksy, A.; Creigh-Pulatmen, T. et al.; Trokter, M.; Fedorova, M.; Atzberger, A.; Strandby, R. B.; Olsen, A. A.; Achiam, M. P.; Matthews, D.; Huber, M.; Groene, H.-J.; Offermanns, S.; Worzfeld, T.: A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers. SCIENCE TRANSLATIONAL MEDICINE 14 (654), eabf1922 (2022)

Kirchhof, L.; Fouani, Y.; Knau, A.; Aslan, G. S.; Heumueller, A. W.; Wittig, I.; Mueller-McNicoll, M.; Dimmeler, S.; Jae, N.: The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm. NON-CODING RNA 8 (4), 49 (2022)

Ehret, E.; Jaeger, Y.; Sergi, C.; Merillat, A.-M.; Peyrollaz, T.; Anand, D.; Wang, Q.; Ino, F.; Maillard, M.; Kellenberger, S. et al.; Gautschi, I.; Szabo, R.; Bugge, T. H.; Vogel, L. K.; Hummler, E.; Frateschi, S.: Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (12), 6745 (2022)

Klockner, I.; Schutt, C.; Gerhardt, T.; Boettger, T.; Braun, T.: Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function. NATURE COMMUNICATIONS 13 (1), 3180 (2022)

Malacarne, P. F.; Ratiu, C.; Gajos-Draus, A.; Mueller, N.; Lopez, M.; Pflueger-Mueller, B.; Ding, X.; Warwick, T.; Oo, J.; Siragusa, M. et al.; Angioni, C.; Guenther, S.; Weigert, A.; Geisslinger, G.; Luetjohann, D.; Schunck, W.-H.; Fleming, I.; Brandes, R. P.; Rezende, F.: Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice. HYPERTENSION 79 (6), pp. 1216 - 1226 (2022)

Liang, G.; Wang, S.; Shao, J.; Jin, Y.-J.; Xu, L.; Yan, Y.; Guenther, S.; Wang, L.; Offermanns, S.: Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis. CIRCULATION RESEARCH 130 (11), pp. 1647 - 1659 (2022)