Publications of Stefan Offermanns

Gurusamy, M.; Tischner, D.; Shao, J.; Klatt, S.; Zukunft, S.; Bonnavion, R.; Guenther, S.; Siebenbrodt, K.; Kestner, R.-I.; Kuhlmann, T. et al.; Fleming, I.; Offermanns, S.; Wettschureck, N.: G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. NATURE COMMUNICATIONS 12 (1), 6798 (2021)

Jin, Y.-J.; Chennupati, R.; Li, R.; Liang, G.; Wang, S.; Iring, A.; Graumann, J.; Wettschureck, N.; Offermanns, S.: Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. JOURNAL OF CLINICAL INVESTIGATION 131 (21), e145734 (2021)

Le Mercier, A.; Bonnavion, R.; Yu, W.; Alnouri, M. W.; Ramas, S.; Zhang, Y.; Jaeger, Y.; Roquid, K. A.; Jeong, H.-W.; Sivaraj, K. K. et al.; Cho, H.; Chen, X.; Strilic, B.; Sijmonsma, T.; Adams, R.; Schroeder, T.; Rieger, M. A.; Offemanns, S.: GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118 (17), e2021596118 (2021)

Lopez, M.; Malacarne, P. F.; Gajos-Draus, A.; Ding, X.; Daiber, A.; Lundberg, J. O.; Offermanns, S.; Brandes, R. P.; Rezende, F.: Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases. BRITISH JOURNAL OF PHARMACOLOGY 178 (7), pp. 1495 - 1506 (2021)

Wang, L.; Chennupati, R.; Jin, Y.-J.; Li, R.; Wang, S.; Guenther, S.; Offermanns, S.: YAP/TAZ Are Required to Suppress Osteogenic Differentiation of Vascular Smooth Muscle Cells. ISCIENCE 23 (12), 101860 (2020)

Nakayama, A.; Albarran-Juarez, J.; Liang, G.; Roquid, K. A.; Iring, A.; Tonack, S.; Chen, M.; Mueller, O. J.; Weinstein, L. S.; Offermanns, S.: Disturbed flow-induced G(s)-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI INSIGHT 5 (23), e140485 (2020)

Wang, L.; Wang, S.; Shi, Y.; Li, R.; Guenther, S.; Ong, Y. T.; Potente, M.; Yuan, Z.; Liu, E.; Offermanns, S.: YAP and TAZ protect against white adipocyte cell death during obesity. NATURE COMMUNICATIONS 11 (1), 5455 (2020)

Kwon, H.-B.; Mackie I, D.; Bonnavion, R.; Le Mercier, A.; Helker, C. S. M.; Son, T.; Guenter, S.; Serafin, D. S.; Kim, K.-W.; Offermanns, S. et al.; Caron, K. M.; Stainier, D. Y. R.: The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE 3 (4), pp. 676 - 689 (2020)

Li, M.; Nishio, S.-y.; Naruse, C.; Riddell, M.; Sapski, S.; Katsuno, T.; Hikita, T.; Mizapourshafiyi, F.; Smith, F. M.; Cooper, L. T. et al.; Lee, M. G.; Asano, M.; Boettger, T.; Krueger, M.; Wietelmann, A.; Graumann, J.; Day, B. W.; Boyd, A. W.; Offermanns, S.; Kitajiri, S.-i.; Usami, S.-i.; Nakayama, M.: Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome. NATURE COMMUNICATIONS 11 (1), 1343 (2020)

Carvalho, J.; Chennupati, R.; Li, R.; Guenther, S.; Kaur, H.; Zhao, W.; Tonack, S.; Kurz, M.; Moesslein, N.; Buenemann, M. et al.; Offermanns, S.; Wettschureck, N.: Orphan G Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling. CIRCULATION 141 (14), pp. 1168 - 1183 (2020)

Khatib-Massalha, E.; Bhattacharya, S.; Massalha, H.; Biram, A.; Golan, K.; Kollet, O.; Kumari, A.; Avemaria, F.; Petrovich-Kopitman, E.; Gur-Cohen, S. et al.; Itkin, T.; Brandenburger, I.; Spiegel, A.; Shulman, Z.; Gerhart-Hines, Z.; Itzkovitz, S.; Gunzer, M.; Offermanns, S.; Alon, R.; Ariel, A.; Lapidot, T.: Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling. NATURE COMMUNICATIONS 11 (1), 3547 (2020)

Wang, S.; Cao, S.; Arhatte, M.; Li, D.; Shi, Y.; Kurz, S.; Hu, J.; Wang, L.; Shao, J.; Atzberger, A. et al.; Wang, Z.; Wang, C.; Zang, W.; Fleming, I.; Wettschureck, N.; Honore, E.; Offermanns, S.: Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. NATURE COMMUNICATIONS 11 (1) (2020)

Chennupati, R.; Wirth, A.; Favre, J.; Li, R.; Bonnavion, R.; Jin, Y.-J.; Wietelmann, A.; Schweda, F.; Wettschureck, N.; Henrion, D. et al.; Offermanns, S.: Myogenic vasoconstriction requires G(12)/G(13) and LARG to maintain local and systemic vascular resistance. ELIFE 8, e49374 (2019)

Helker, C. S. M.; Mullapudi, S.-T.; Mueller, L. M.; Preussner, J.; Tunaru, S.; Skog, O.; Kwon, H.-B.; Kreuder, F.; Lancman, J. J.; Bonnavion, R. et al.; Dong, P. D. S.; Looso, M.; Offermanns, S.; Korsgren, O.; Spagnoli, F. M.; Stainier, D. Y. R.: A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development. DEVELOPMENT 146 (14), UNSP dev172569 (2019)

Yang, L.; Joseph, S.; Sun, T.; Hoffmann, J.; Thevissen, S.; Offermanns, S.; Strilic, B.: TAK1 regulates endothelial cell necroptosis and tumor metastasis. CELL DEATH AND DIFFERENTIATION 26 (10), pp. 1987 - 1997 (2019)

Yin, W.; Kim, H.-T.; Wang, S.; Gunawan, F.; Li, R.; Buettner, C.; Grohmann, B.; Sengle, G.; Sinner, D.; Offermanns, S. et al.; Stainier, D. Y. R.: Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis. EUROPEAN RESPIRATORY JOURNAL 53 (3), 1800840 (2019)

Albarran-Juarez, J.; Iring, A.; Wang, S.; Joseph, S.; Grimm, M.; Strilic, B.; Wettschureck, N.; Althoff, T. F.; Offermanns, S.: Piezo1 and G(q)/G(11) promote endothelial inflammation depending on flow pattern and integrin activation. JOURNAL OF EXPERIMENTAL MEDICINE 215 (10), pp. 2655 - 2672 (2018)

Tunaru, S.; Bonnavion, R.; Brandenburger, I.; Preussner, J.; Thomas, D.; Scholich, K.; Offermanns, S.: 20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1. NATURE COMMUNICATIONS 9, 177 (2018)

Yin, W.; Kim, H.-T.; Wang, S.; Gunawan, F.; Wang, L.; Kishimoto, K.; Zhong, H.; Roman, D.; Preussner, J.; Guenther, S. et al.; Graef, V.; Buettner, C.; Grohmann, B.; Looso, M.; Morimoto, M.; Mardon, G.; Offermanns, S.; Stainier, D. Y. R.: The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. NATURE COMMUNICATIONS 9, 2815 (2018)

Kaur, H.; Carvalho, J.; Looso, M.; Singh, P.; Chennupati, R.; Preussner, J.; Guenther, S.; Albarran-Juarez, J.; Tischner, D.; Classen, S. et al.; Offermanns, S.; Wettschureck, N.: Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system. NATURE COMMUNICATIONS 8, 15700 (2017)