Publications of Mario Looso

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), pp. 674 - 682 (2025)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, P. M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Ribeiro da Silva, A.; Gunawan, F.; Boezio, G. L. M.; Faure , E.; Theron , A.; Avierinos , J.-F.; Lim, S.; Shivam, G. J.; Ramadass, R.; Guenther, S. et al.; Looso, M.; Zaffran, S.; Juan, T.; Stainier, D. Y. R.: egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. SCIENCE ADVANCES 10 (20), eadl0633 (2024)

Vega-Sendino, M.; Luettmann, F. F.; Olbrich, T.; Chen, Y.; Kuenne, C.; Stein, P.; Tillo, D.; Carey, G. I.; Zhong, J.; Savy, V. et al.; Radonova, L.; Lu, T.; Saykali, B.; Kim, K.-P.; Domingo, C. N.; Schueler, L.; Guenther, S.; Bentsen, M.; Bosnakovski, D.; Schoeler, H.; Kyba, M.; Maity, T. K.; Jenkins, L. M.; Looso, M.; Williams, C. J.; Kim, J.; Ruiz, S.: The homeobox transcription factor DUXBL controls exit from totipotency. NATURE GENETICS (56), pp. 697 - 709 (2024)

Wu, F.; Li, X.; Looso, M.; Liu, H.; Ding, D.; Guenther, S.; Kuenne, C.; Liu, S.; Weissmann, N.; Boettger, T. et al.; Atzberger, A.; Kolahian, S.; Renz, H.; Offermanns, S.; Gaertner, U.; Potente, M.; Zhou, Y.; Yuan, X.; Braun, T.: Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. NATURE GENETICS 55 (1), pp. 100 - + (2024)

Hu, J.; Leisegang, M. S.; Looso, M.; Drekolia, M.-K.; Wittig, J.; Mettner, J.; Karantanou, C.; Kyselova, A.; Dumbovic, G.; Li, X. et al.; Li, Y.; Guenther, S.; John, D.; Siragusa, M.; Zukunft, S.; Oo, J.; Wittig, I.; Hille, S.; Weigert, A.; Knapp, S.; Brandes, R. P.; Muller, O. J.; Papapetropoulos, A.; Sigala, F.; Dobreva, G.; Kojonazarov, B.; Fleming, I.; Bibli, S.-I.: Disrupted Binding of Cystathionine gamma-Lyase to p53 Promotes Endothelial Senescence. Circulation research (2023)

Li, X.; Wu, F.; Guenther, S.; Looso, M.; Kuenne, C.; Zhang, T.; Wiesnet, M.; Klatt, S.; Zukunft, S.; Fleming, I. et al.; Poschet, G.; Wietelmann, A.; Atzberger, A.; Potente, M.; Yuan, X.; Braun, T.: Inhibition of fatty acid oxidation enables heart regeneration in adult mice. NATURE (2023)

Khassafi, F.; Chelladurai, P.; Valasarajan, C.; Nayakanti, S. R.; Martineau, S.; Sommer, N.; Yokokawa, T.; Boucherat, O.; Kamal, A.; Kiely, D. G. et al.; Swift, A. J.; Alabed, S.; Omura, J.; Breuils-Bonnet, S.; Kuenne, C.; Potus, F.; Guenther, S.; Savai, R.; Seeger, W.; Looso, M.; Zaugg, J. B.; Tello, K.; Provencher, S.; Bonnet, S.; Pullamsetti, S. S.: Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. NATURE CARDIOVASCULAR RESEARCH 2 (10), pp. 917 - + (2023)

Nayakanti, S. R.; Friedrich, A.; Sarode, P.; Jafari, L.; Maroli, G.; Boehm, M.; Bourgeois, A.; Grobs, Y.; Khassafi, F.; Kuenne, C. et al.; Guenther, S.; Dabral, S.; Wilhelm, J.; Weiss, A.; Wietelmann, A.; Kojonazarov, B.; Janssen, W.; Looso, M.; de Man, F.; Provencher, S.; Tello, K.; Seeger, W.; Bonnet, S.; Savai, R.; Schermuly, R.; Pullamsetti, S. S.: Targeting Wnt-ss-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling. CIRCULATION RESEARCH 132 (11), pp. 1468 - 1485 (2023)

Wu, F.; Li, X.; Looso, M.; Liu, H.; Ding, D.; Guenther, S.; Kuenne, C.; Liu, S.; Weissmann, N.; Boettger, T. et al.; Atzberger, A.; Kolahian, S.; Renz, H.; Offermanns, S.; Gaertner, U.; Potente, M.; Zhou, Y.; Yuan, X.; Braun, T.: Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. NATURE GENETICS (2023; 55(1)), pp. 100 - 111 (2023)

Leisegang, M. S.; Bains, J. K.; Seredinski, S.; Oo, J. A.; Krause, N. M.; Kuo, C.-C.; Guenther, S.; Cetin, N. S.; Warwick, T.; Cao, C. et al.; Boos, F.; Ponce, J. I.; Haydar, S.; Bednarz, R.; Valasarajan, C.; Fuhrmann, D. C.; Preussner, J.; Looso, M.; Pullamsetti, S. S.; Schulz, M. H.; Jonker, H. R. A.; Richter, C.; Rezende, F.; Gilsbach, R.; Pflueger-Mueller, B.; Wittig, I.; Grummt, I.; Ribarska, T.; Costa, I. G.; Schwalbe, H.; Brandes, R. P.: HIF1 alpha-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex. NATURE COMMUNICATIONS 13 (1), 6563 (2022)

Allanki, S.; Strilic, B.; Scheinberger, L.; Onderwater, Y. L.; Marks, A.; Guenther, S.; Preussner, J.; Kikhi, K.; Looso, M.; Stainier, D. Y. R. et al.; Reischauer, S.: Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. SCIENCE ADVANCES 7 (37), eabg6497 (2021)

Pflueger-Mueller, B.; Oo, J. A.; Heering, J.; Warwick, T.; Proschak, E.; Guenther, S.; Looso, M.; Rezende, F.; Fork, C.; Geisslinger, G. et al.; Thomas, D.; Gurke, R.; Steinhilber, D.; Schulz, M.; Leisegang, M. S.; Brandes, R. P.: The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells. BASIC RESEARCH IN CARDIOLOGY 115 (3), 34 (2020)

Helker, C. S. M.; Mullapudi, S.-T.; Mueller, L. M.; Preussner, J.; Tunaru, S.; Skog, O.; Kwon, H.-B.; Kreuder, F.; Lancman, J. J.; Bonnavion, R. et al.; Dong, P. D. S.; Looso, M.; Offermanns, S.; Korsgren, O.; Spagnoli, F. M.; Stainier, D. Y. R.: A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development. DEVELOPMENT 146 (14), UNSP dev172569 (2019)

Leisegang, M. S.; Bibli, S.-I.; Guenther, S.; Pflueger-Mueller, B.; Oo, J. A.; Hoeper, C.; Seredinski, S.; Yekelchyk, M.; Schmitz-Rixen, T.; Schuermann, C. et al.; Hu, J.; Looso, M.; Sigala, F.; Boon, R. A.; Fleming, I.; Brandes, R. P.: Pleiotropic effects of laminar flow and statins depend on the Kruppel-like factor-induced lncRNA MANTIS. EUROPEAN HEART JOURNAL 40 (30), pp. 2523 - 2533 (2019)

Preussner, J.; Zhong, J.; Looso, M.; Braun, T.; Kim, J.: Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators. MOLECULAR & CELLULAR ONCOLOGY 6 (2), e1565469 (2019)

Jia, G.; Preussner, J.; Chen, X.; Guenther, S.; Yuan, X.; Yekelchyk, M.; Kuenne, C.; Looso, M.; Zhou, Y.; Teichmann, S. et al.; Braun, T.: Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement. NATURE COMMUNICATIONS 9, 4877 (2018)

Preussner, J.; Zhong, J.; Sreenivasan, K.; Guenther, S.; Engleitner, T.; Kuenne, C.; Glatzel, M.; Rad, R.; Looso, M.; Braun, T. et al.; Kim, J.: Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype. CELL STEM CELL 23 (6), pp. 794 - + (2018)

Riddell, M.; Nakayama, A.; Hikita, T.; Mirzapourshafiyi, F.; Kawamura, T.; Pasha, A.; Li, M.; Masuzawa, M.; Looso, M.; Steinbacher, T. et al.; Ebnet, K.; Potente, M.; Hirose, T.; Ohno, S.; Fleming, I.; Gattenloehner, S.; Aung, P. P.; Thuy, P.; Yamasaki, O.; Yanagi, T.; Umemura, H.; Nakayama, M.: aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability. NATURE COMMUNICATIONS 9, 5357 (2018)

Yin, W.; Kim, H.-T.; Wang, S.; Gunawan, F.; Wang, L.; Kishimoto, K.; Zhong, H.; Roman, D.; Preussner, J.; Guenther, S. et al.; Graef, V.; Buettner, C.; Grohmann, B.; Looso, M.; Morimoto, M.; Mardon, G.; Offermanns, S.; Stainier, D. Y. R.: The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. NATURE COMMUNICATIONS 9, 2815 (2018)