Publications of Stefan Guenther

Kwon, J.; Haruya, K.; Mattonet, K.; Guenther, S.; Hahnefeld, L.; Shamsara, J.; Heering, J.; Kurz, M.; Kirchhofer, S.; Krasel, C. et al.; Ulrich, M.; Persechino, M.; Murthy, S.; Orlandi, C.; Sadik, C. D.; Geisslinger, G.; Buenemann, M.; Kolb, P.; Offermanns, S.; Wettschureck, N.: Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling. NATURE COMMUNICATIONS 16 (1), 1448 (2025)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, P. M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Teichmann, T.; Pflueger-Mueller, B.; Gimenez, V. M. M.; Sailer, F.; Dirks, H.; Zehr, S.; Warwick, T.; Brettner, F.; Munoz-Tello, P.; Zimmer, A. et al.; Tegeder, I.; Thomas, D.; Gurke, R.; Guenther, S.; Heering, J.; Proschak, E.; Geisslinger, G.; Bibli, I.-S.; zu Heringdorf, D. M.; Manucha, W.; Windbergs, M.; Knapp, S.; Weigert, A.; Leisegang, M. S.; Kojetin, D.; Brandes, R. P.: The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors. BRITISH JOURNAL OF PHARMACOLOGY (2024)

Alnouri, M. W.; Roquid, K. A.; Bonnavion, R.; Cho, H.; Heering, J.; Kwon, J.; Jaeger, Y.; Wang, S.; Guenther, S.; Wettschureck, N. et al.; Geisslingerb, G.; Gurke, R.; Mueller, C. E.; Proschak, E.; Offermanns, S.: SPMs exert anti- inflammatory and pro- resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (41), e2407130121 (2024)

Weiss, L. M.; Warwick, T.; Zehr, S.; Guenther, S.; Wolf, S.; Schmachtel, T.; Ponce, J. I.; Palfi, K.; Teichmann, T.; Schneider, A. et al.; Stoetzel, J.; Knapp, S.; Weigert, A.; Savai, R.; Rieger, M. A.; Oellerich, T.; Wittig, I.; Oo, J. A.; Brandes, R. P.; Leisegang, M. S.: RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions. COMMUNICATIONS BIOLOGY 7 (1), 1131 (2024)

Maroli, G.; Scha, A.; Guenther, S.; -Gonzalez, C. G.; Rupp, S.; Schlierbach, H.; Chen, Y.; Graumann, J.; Wietelmann, A.; Kim, J. et al.; Braun, T.: Inhibition of autophagy prevents cardiac dysfunction at early stages of cardiomyopathy in Bag3-deficient hearts. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 193, pp. 53 - 66 (2024)

Peng, Y.; Du, J.; Li, R.; Guenther, S.; Wettschureck, N.; Offermanns, S.; Wang, Y.; Schneider, A.; Braun, T.: RhoA-mediated G₁₂-G₁₃ signaling maintains muscle stem cell quiescence and prevents stem cell loss. CELL DISCOVERY 10 (1), 76 (2024)

Kumari, P.; Tarighi, S.; Fuchshuber, E.; Li, L.; Fernandez-Duran, I.; Wang, M.; Ayoson, J.; Castello-Garcia, J. M.; Gamez-Garcia, A.; Espinosa-Alcantud, M. et al.; Sreenivasan, K.; Guenther, S.; Olivella, M.; Savai, R.; Yue, S.; Vaquero, A.; Braun, T.; Ianni, A.: SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (25), e2409269121 (2024)

Ribeiro da Silva, A.; Gunawan, F.; Boezio, G. L. M.; Faure , E.; Theron , A.; Avierinos , J.-F.; Lim, S.; Shivam, G. J.; Ramadass, R.; Guenther, S. et al.; Looso, M.; Zaffran, S.; Juan, T.; Stainier, D. Y. R.: egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. SCIENCE ADVANCES 10 (20), eadl0633 (2024)

Tamiato, A.; Tombor, L. S.; Fischer, A.; Muhly-Reinholz, M.; Vanicek, L. R.; Togru, B. N.; Neitz, J.; Glaser, S. F.; Merten, M.; Morales, D. R. et al.; Kwon, J.; Klatt, S.; Schumacher, B.; Guenther, S.; Abplanalp, W. T.; John, D.; Fleming, I.; Wettschureck, N.; Dimmeler, S.; Luxaen, G.: Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis. CIRCULATION RESEARCH 134 (10), pp. 1240 - 1255 (2024)

Wang, T.; Shao, J.; Shamit, K.; Alnouri, M. W.; Carvalho, J.; Guenther, S.; Krasel , C.; Murphy, K. T.; Buenemann, M.; Offermanns, S. et al.; Wettschureck, N.: Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction. CIRCULATION RESEARCH 134 (10), pp. 1259 - 1275 (2024)

Vega-Sendino, M.; Luettmann, F. F.; Olbrich, T.; Chen, Y.; Kuenne, C.; Stein, P.; Tillo, D.; Carey, G. I.; Zhong, J.; Savy, V. et al.; Radonova, L.; Lu, T.; Saykali, B.; Kim, K.-P.; Domingo, C. N.; Schueler, L.; Guenther, S.; Bentsen, M.; Bosnakovski, D.; Schoeler, H.; Kyba, M.; Maity, T. K.; Jenkins, L. M.; Looso, M.; Williams, C. J.; Kim, J.; Ruiz, S.: The homeobox transcription factor DUXBL controls exit from totipotency. NATURE GENETICS (56), pp. 697 - 709 (2024)

Teichmann, T.; Malacarne, P.; Zehr, S.; Guenther, S.; Pflueger-Mueller, B.; Warwick, T.; Brandes, R. P.: NCoR1 limits angiogenic capacity by altering Notch signaling. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 188, pp. 65 - 78 (2024)

Weiss, M.; Hettrich, S.; Hofmann, T.; Hachim, S.; Guenther, S.; Braun, T.; Boettger, T.: Mitolnc controls cardiac BCAA metabolism and heart hypertrophy by allosteric activation of BCKDH. NUCLEIC ACIDS RESEARCH (2024)

Wu, F.; Li, X.; Looso, M.; Liu, H.; Ding, D.; Guenther, S.; Kuenne, C.; Liu, S.; Weissmann, N.; Boettger, T. et al.; Atzberger, A.; Kolahian, S.; Renz, H.; Offermanns, S.; Gaertner, U.; Potente, M.; Zhou, Y.; Yuan, X.; Braun, T.: Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. NATURE GENETICS 55 (1), pp. 100 - + (2024)

Hu, J.; Leisegang, M. S.; Looso, M.; Drekolia, M.-K.; Wittig, J.; Mettner, J.; Karantanou, C.; Kyselova, A.; Dumbovic, G.; Li, X. et al.; Li, Y.; Guenther, S.; John, D.; Siragusa, M.; Zukunft, S.; Oo, J.; Wittig, I.; Hille, S.; Weigert, A.; Knapp, S.; Brandes, R. P.; Muller, O. J.; Papapetropoulos, A.; Sigala, F.; Dobreva, G.; Kojonazarov, B.; Fleming, I.; Bibli, S.-I.: Disrupted Binding of Cystathionine gamma-Lyase to p53 Promotes Endothelial Senescence. Circulation research (2023)

Li, X.; Wu, F.; Guenther, S.; Looso, M.; Kuenne, C.; Zhang, T.; Wiesnet, M.; Klatt, S.; Zukunft, S.; Fleming, I. et al.; Poschet, G.; Wietelmann, A.; Atzberger, A.; Potente, M.; Yuan, X.; Braun, T.: Inhibition of fatty acid oxidation enables heart regeneration in adult mice. NATURE (2023)

Khassafi, F.; Chelladurai, P.; Valasarajan, C.; Nayakanti, S. R.; Martineau, S.; Sommer, N.; Yokokawa, T.; Boucherat, O.; Kamal, A.; Kiely, D. G. et al.; Swift, A. J.; Alabed, S.; Omura, J.; Breuils-Bonnet, S.; Kuenne, C.; Potus, F.; Guenther, S.; Savai, R.; Seeger, W.; Looso, M.; Zaugg, J. B.; Tello, K.; Provencher, S.; Bonnet, S.; Pullamsetti, S. S.: Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. NATURE CARDIOVASCULAR RESEARCH 2 (10), pp. 917 - + (2023)

Loerchner, H.; Esteve, L. C.; Goes, M. E.; Harzenetter, R.; Brachmann, N.; Gajawada, P.; Guenther, S.; Doll, N.; Poeling, J.; Braun, T.: Neutrophils for Revascularization Require Activation of CCR6 and CCL20 by TNFα. CIRCULATION RESEARCH 133 (7), pp. 592 - 610 (2023)

Karger, A.; Mansouri, S.; Leisegang , M. S.; Weigert, A.; Guenther, S.; Kuenne, C.; Wittig , I.; Zukunft , S.; Klatt , S.; Aliraj , B. et al.; Klotz V , L.; Winter , H.; Mahavadi, P.; Fleming , I.; Ruppert , C.; Witte , B.; Alkoudmani , I.; Gattenloehner, S.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth. EMBO JOURNAL (2023)