Publications of Werner Seeger

Khassafi, F.; Chelladurai, P.; Valasarajan, C.; Nayakanti, S. R.; Martineau, S.; Sommer, N.; Yokokawa, T.; Boucherat, O.; Kamal, A.; Kiely, D. G. et al.; Swift, A. J.; Alabed, S.; Omura, J.; Breuils-Bonnet, S.; Kuenne, C.; Potus, F.; Guenther, S.; Savai, R.; Seeger, W.; Looso, M.; Zaugg, J. B.; Tello, K.; Provencher, S.; Bonnet, S.; Pullamsetti, S. S.: Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. NATURE CARDIOVASCULAR RESEARCH 2 (10), pp. 917 - + (2023)

Karger, A.; Mansouri, S.; Leisegang , M. S.; Weigert, A.; Guenther, S.; Kuenne, C.; Wittig , I.; Zukunft , S.; Klatt , S.; Aliraj , B. et al.; Klotz V , L.; Winter , H.; Mahavadi, P.; Fleming , I.; Ruppert , C.; Witte , B.; Alkoudmani , I.; Gattenloehner, S.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth. EMBO JOURNAL (2023)

Zheng, X.; Sarode, P.; Weigert , A.; Turkowski, K.; Chelladurai, P.; Guenther, S.; Kuenne, C.; Winter , H.; Stenzinger, A.; Reu, S. et al.; Grimminger, F.; Stiewe, T.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization. CANCER RESEARCH 83 (14), pp. 2345 - 2357 (2023)

Nayakanti, S. R.; Friedrich, A.; Sarode, P.; Jafari, L.; Maroli, G.; Boehm, M.; Bourgeois, A.; Grobs, Y.; Khassafi, F.; Kuenne, C. et al.; Guenther, S.; Dabral, S.; Wilhelm, J.; Weiss, A.; Wietelmann, A.; Kojonazarov, B.; Janssen, W.; Looso, M.; de Man, F.; Provencher, S.; Tello, K.; Seeger, W.; Bonnet, S.; Savai, R.; Schermuly, R.; Pullamsetti, S. S.: Targeting Wnt-ss-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling. CIRCULATION RESEARCH 132 (11), pp. 1468 - 1485 (2023)

Weigert, A.; Zheng, X.; Nenzel, A.; Turkowski, K.; Guenther, S.; Strack, E.; Sirait-Fischer, E.; Elwakeel, E.; Kur, I. M.; Nikam, V. S. et al.; Valasarajan, C.; Winter, H.; Wissgott, A.; Voswinkel, R.; Grimminger, F.; Brune, B.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system. NATURE COMMUNICATIONS 13 (1), 6078 (2022)

Selle, J.; Dinger, K.; Jentgen, V.; Zanetti, D.; Will, J.; Georgomanolis, T.; Vohlen, C.; Wilke, R.; Kojonazarov, B.; Klymenko, O. et al.; Mohr, J.; Koningsbruggen-Rietschel, S. v.; Rhodes, C. J.; Ulrich, A.; Hirani, D.; Nestler, T.; Odenthal, M.; Mahabir, E.; Nayakanti, S.; Dabral, S.; Wunderlich, T.; Priest, J.; Seeger, W.; Doetsch, J.; Pullamsetti, S. S.; Alcazar, M. A. A.: Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life. NATURE COMMUNICATIONS 13 (1), 4352 (2022)

Karger, A.; Nandigama, R.; Stenzinger, A.; Grimminger, F.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Hidden Treasures: Macrophage Long Non-Coding RNAs in Lung Cancer Progression. CANCERS 13 (16), 4127 (2021)

Zheng, X.; Mansouri, S.; Krager, A.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Wheelock, C. E.; Savai, R.: Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment. EUROPEAN RESPIRATORY REVIEW 29 (157), 200134 (2020)

El-Nikhely, N.; Karger, A.; Sarode, P.; Singh, I.; Weigert, A.; Wietelmann, A.; Stiewe, T.; Dammann, R.; Fink, L.; Grimminger, F. et al.; Barreto, G.; Seeger, W.; Pullamsetti, S. S.; Rapp, U. R.; Savai, R.: Metastasis-Associated Protein 2 Represses NF-kappa B to Reduce Lung Tumor Growth and Inflammation. CANCER RESEARCH 80 (19), pp. 4199 - 4211 (2020)

Salazar, Y.; Zheng, X.; Brunn, D.; Raifer, H.; Picard, F.; Zhang, Y.; Winter, H.; Guenther, S.; Weigert, A.; Weigmann, B. et al.; Dumoutier, L.; Renauld, J.-C.; Waisman, A.; Schmall, A.; Tufman, A.; Fink, L.; Bruene, B.; Bopp, T.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Huber, M.; Savai, R.: Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer. JOURNAL OF CLINICAL INVESTIGATION 130 (7), pp. 3560 - 3575 (2020)

Sarode, P.; Mansouri, S.; Karger, A.; Schaefer, M. B.; Grimminger, F.; Seeger, W.; Savai, R.: Epithelial cell plasticity defines heterogeneity in lung cancer. CELLULAR SIGNALLING 65, 109463 (2020)

Sarode, P.; Zheng, X.; Giotopoulou, G. A.; Weigert, A.; Kuenne, C.; Guenther, S.; Friedrich, A.; Gattenloehner, S.; Stiewe, T.; Bruene, B. et al.; Grimminger, F.; Stathopoulos, G. T.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Reprogramming of tumor-associated macrophages by targeting beta-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer. SCIENCE ADVANCES 6 (23), eaaz6105 (2020)

Zheng, X.; Weigert, A.; Reu, S.; Guenther, S.; Mansouri, S.; Bassaly, B.; Gattenlohner, S.; Grimminger, F.; Pullamsetti, S. S.; Seeger, W. et al.; Winter, H.; Savai, R.: Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small Cell Lung Carcinoma. CANCER RESEARCH 80 (20), pp. 4414 - 4425 (2020)

Jia, Y.; Vong, J. S.-L.; Asafova, A.; Garvalov, B. K.; Caputo, L.; Cordero, J.; Singh, A.; Boettger, T.; Guenther, S.; Fink, L. et al.; Acker, T.; Barreto, G.; Seeger, W.; Braun, T.; Savai, R.; Dobreva, G.: Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET. JOURNAL OF EXPERIMENTAL MEDICINE 216 (6), pp. 1377 - 1395 (2019)

Sarode, P.; Zheng, X.; Weigert, A.; Tretyn, A.; Guenther, S.; Pullamsetti, S. S.; Grimminger, F.; Seeger, W.; Savai, R.: Reprogramming of Tumor Associated Macrophages by Modulating Wnt beta-Catenin Signalling in Lung Cancer. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 197 (2018)

Savai, R.; Asafova, A.; Zheng, X.; Schmall, A.; Weigert, A.; Pullamsetti, S. S.; Seeger, W.: Circulating Fibrocytes Depletion Results In Reduced Lung Tumor Growth And Metastasis By Modulating Macrophage Phenotype, Angiogenesis And Endothelin System. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 195 (2017)

Zheng, X.; Sarode, P.; Weigert, A.; Guenther, S.; Chelladurai, P.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Re-Education Of Tumor-Associated Macrophages By Modulating Histone Deacetylases In Lung Cancer. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 195 (2017)

Zheng, X.; Turkowski, K.; Mora, J.; Brne, B.; Seeger, W.; Weigert, A.; Savai, R.: Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy. ONCOTARGET 8 (29), pp. 48436 - 48452 (2017)