Publications of IMPRS students

Oo, J. A.; Palfi, K.; Warwick, T.; Wittig, I.; Prieto-Garcia, C.; Matkovic, V.; Tomaskovic, I.; Boos, F.; Izquierdo Ponce, J.; Teichmann, T. et al.; Petriukov, K.; Haydar, S.; Maegdefessel, L.; Wu, Z.; Pham, M. D.; Krishnan, J.; Baker, A. H.; Gunther, S.; Ulrich, H. D.; Dikic, I.; Leisegang, M. S.; Brandes, R. P.: Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2. Cell reports 41 (7) (2022)

Leisegang, M. S.; Bains, J. K.; Seredinski, S.; Oo, J. A.; Krause, N. M.; Kuo, C.-C.; Gunther, S.; Senturk Cetin, N.; Warwick, T.; Cao, C. et al.; Boos, F.; Izquierdo Ponce, J.; Haydar, S.; Bednarz, R.; Valasarajan, C.; Fuhrmann, D. C.; Preussner, J.; Looso, M.; Pullamsetti, S. S.; Schulz, M. H.; Jonker, H. R. A.; Richter, C.; Rezende, F.; Gilsbach, R.; Pfluger-Muller, B.; Wittig, I.; Grummt, I.; Ribarska, T.; Costa, I. G.; Schwalbe, H.; Brandes, R. P.: HIF1alpha-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex. Nature communications 13 (1), 6563 (2022)

Leisegang, M. S.; Bains, J. K.; Seredinski, S.; Oo, J. A.; Krause, N. M.; Kuo, C.-C.; Guenther, S.; Cetin, N. S.; Warwick, T.; Cao, C. et al.; Boos, F.; Ponce, J. I.; Haydar, S.; Bednarz, R.; Valasarajan, C.; Fuhrmann, D. C.; Preussner, J.; Looso, M.; Pullamsetti, S. S.; Schulz, M. H.; Jonker, H. R. A.; Richter, C.; Rezende, F.; Gilsbach, R.; Pflueger-Mueller, B.; Wittig, I.; Grummt, I.; Ribarska, T.; Costa, I. G.; Schwalbe, H.; Brandes, R. P.: HIF1 alpha-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex. NATURE COMMUNICATIONS 13 (1), 6563 (2022)

Weigert, A.; Zheng, X.; Nenzel, A.; Turkowski, K.; Guenther, S.; Strack, E.; Sirait-Fischer, E.; Elwakeel, E.; Kur, I. M.; Nikam, V. S. et al.; Valasarajan, C.; Winter, H.; Wissgott, A.; Voswinkel, R.; Grimminger, F.; Brune, B.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system. NATURE COMMUNICATIONS 13 (1), 6078 (2022)

Garcia-Gonzalez, C.; Dieterich, C.; Maroli, G.; Wiesnet, M.; Wietelmann, A.; Li, X.; Yuan, X.; Graumann, J.; Stellos, K.; Kubin, T. et al.; Schneider, A.; Braun, T.: ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7. CIRCULATION RESEARCH 131 (7), pp. 580 - 597 (2022)

Mattonet, K.; Riemslagh, F. W.; Guenther, S.; Prummel, K. D.; Kesavan, G.; Hans, S.; Ebersberger, I.; Brand, M.; Burger, A.; Reischauer, S. et al.; Mosimann, C.; Stainier, D. Y. R.: Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2. SCIENCE ADVANCES 8 (35), eabn2082 (2022)

Selle, J.; Dinger, K.; Jentgen, V.; Zanetti, D.; Will, J.; Georgomanolis, T.; Vohlen, C.; Wilke, R.; Kojonazarov, B.; Klymenko, O. et al.; Mohr, J.; Koningsbruggen-Rietschel, S. v.; Rhodes, C. J.; Ulrich, A.; Hirani, D.; Nestler, T.; Odenthal, M.; Mahabir, E.; Nayakanti, S.; Dabral, S.; Wunderlich, T.; Priest, J.; Seeger, W.; Doetsch, J.; Pullamsetti, S. S.; Alcazar, M. A. A.: Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life. NATURE COMMUNICATIONS 13 (1), 4352 (2022)

Hu, B.; Lelek, S.; Spanjaard, B.; El-Sammak, H.; Simoes, M. G.; Mintcheva, J.; Aliee, H.; Schaefer, R.; Meyer, A. M.; Theis, F. et al.; Stainier, D. Y. R.; Panakova, D.; Junker, J. P.: Origin and function of activated fibroblast states during zebrafish heart regeneration. NATURE GENETICS (2022)

Georgieva, A. M.; Guo, X.; Bartkuhn, M.; Guenther, S.; Kuenne, C.; Smolka, C.; Atzberger, A.; Gaertner, U.; Mamchaoui, K.; Bober, E. et al.; Zhou, Y.; Yuan, X.; Braun, T.: Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression. NATURE COMMUNICATIONS 13 (1), 4184 (2022)

Xu, R.; Hoess, C.; Swiercz, J. M.; Brandt, D. T.; Lutz, V.; Petersen, N.; Li, R.; Zhao, D.; Oleksy, A.; Creigh-Pulatmen, T. et al.; Trokter, M.; Fedorova, M.; Atzberger, A.; Strandby, R. B.; Olsen, A. A.; Achiam, M. P.; Matthews, D.; Huber, M.; Groene, H.-J.; Offermanns, S.; Worzfeld, T.: A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers. SCIENCE TRANSLATIONAL MEDICINE 14 (654), eabf1922 (2022)

Kirchhof, L.; Fouani, Y.; Knau, A.; Aslan, G. S.; Heumueller, A. W.; Wittig, I.; Mueller-McNicoll, M.; Dimmeler, S.; Jae, N.: The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm. NON-CODING RNA 8 (4), 49 (2022)

Ehret, E.; Jaeger, Y.; Sergi, C.; Merillat, A.-M.; Peyrollaz, T.; Anand, D.; Wang, Q.; Ino, F.; Maillard, M.; Kellenberger, S. et al.; Gautschi, I.; Szabo, R.; Bugge, T. H.; Vogel, L. K.; Hummler, E.; Frateschi, S.: Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (12), 6745 (2022)

Klockner, I.; Schutt, C.; Gerhardt, T.; Boettger, T.; Braun, T.: Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function. NATURE COMMUNICATIONS 13 (1), 3180 (2022)

Malacarne, P. F.; Ratiu, C.; Gajos-Draus, A.; Mueller, N.; Lopez, M.; Pflueger-Mueller, B.; Ding, X.; Warwick, T.; Oo, J.; Siragusa, M. et al.; Angioni, C.; Guenther, S.; Weigert, A.; Geisslinger, G.; Luetjohann, D.; Schunck, W.-H.; Fleming, I.; Brandes, R. P.; Rezende, F.: Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice. HYPERTENSION 79 (6), pp. 1216 - 1226 (2022)

Liang, G.; Wang, S.; Shao, J.; Jin, Y.-J.; Xu, L.; Yan, Y.; Guenther, S.; Wang, L.; Offermanns, S.: Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis. CIRCULATION RESEARCH 130 (11), pp. 1647 - 1659 (2022)

Malacarne, P. F.; Bezzenberger, J.; Lopez, M.; Warwick, T.; Mueller, N.; Brandes, R. P.; Rezende, F.: Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular Tone. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (11), 5939 (2022)

Chu, Z.; Gu, L.; Hu, Y.; Zhang, X.; Li, M.; Chen, J.; Teng, D.; Huang, M.; Shen, C.-H.; Cai, L. et al.; Yoshida, T.; Qi, Y.; Niu, Z.; Feng, A.; Geng, S.; Frederick, D. T.; Specht, E.; Piris, A.; Sullivan, R. J.; Flaherty, K. T.; Boland, G. M.; Georgopoulos, K.; Liu, D.; Shi, Y.; Zheng, B.: STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming. NATURE COMMUNICATIONS 13 (1), 1859 (2022)

Yang, Y. H. C.; Briant, L. J. B.; Raab, C. A.; Mullapudi, S. T.; Maischein, H.-M.; Kawakami, K.; Stainier, D. Y. R.:

Innervation modulates the functional connectivity between pancreatic endocrine cells

. ELIFE 11, e64526 (2022)

Peng, Y.; Du, J.; Gunther, S.; Guo, X.; Wang, S.; Schneider, A.; Zhu, L.; Braun, T.: Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells. REDOX BIOLOGY 52, 102309 (2022)

El-Sammak, H.; Yang, B.; Guenther, S.; Chen, W.; Marin-Juez, R.; Stainier, D. Y. R.: A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. CIRCULATION RESEARCH 130 (7), pp. 1014 - 1029 (2022)

Seredinski, S.; Boos, F.; Guenther, S.; Oo, J. A.; Warwick, T.; Ponce, J. I.; Lillich, F. F.; Proschak, E.; Knapp, S.; Gilsbach, R. et al.; Pflueger-Mueller, B.; Brandes, R. P.; Leisegang, M. S.: DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells. MOLECULAR THERAPY-NUCLEIC ACIDS 27, pp. 1023 - 1035 (2022)

Keshavarz, M.; Tabrizi, S. F.; Ruppert, A.-L.; Pfeil, U.; Schreiber, Y.; Klein, J.; Brandenburger, I.; Lochnit, G.; Bhushan, S.; Perniss, A. et al.; Deckmann, K.; Hartmann, P.; Meiners, M.; Mermer, P.; Rafiq, A.; Winterberg, S.; Papadakis, T.; Thomas, D.; Angioni, C.; Oberwinkler, J.; Chubanov, V.; Gudermann, T.; Gaertner, U.; Offermanns, S.; Schuetz, B.; Kummer, W.: Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmitters. SCIENCE IMMUNOLOGY 7 (69), eabf6734 (2022)

Qi, J.; Rittershaus, A.; Priya, R.; Mansingh, S.; Stainier, D. Y. R.; Helker, C. S. M.; Bautch, V. L.: Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. ELIFE 11, e73231 (2022)

Muller, N.; Warwick, T.; Noack, K.; Malacarne, P. F.; Cooper, A. J. L.; Weissmann, N.; Schroder, K.; Brandes, R. P.; Rezende, F.: Reactive Oxygen Species Differentially Modulate the Metabolic and Transcriptomic Response of Endothelial Cells. Antioxidants (Basel, Switzerland) 11 (2), p. 434 (2022)

Heumueller, A. W.; Jones, A. N.; Mourao, A.; Klangwart, M.; Shi, C.; Wittig, I.; Fischer, A.; Muhly-Reinholz, M.; Buchmann, G. K.; Dieterich, C. et al.; Potente, M.; Braun, T.; Grote, P.; Jae, N.; Sattler, M.; Dimmeler, S.: Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses. CIRCULATION RESEARCH 130 (1), pp. 67 - 79 (2022)